APPENDIX C

ACUTE EXPOSURE GUIDELINE LEVELS FOR n-HEXANE

Derivation Summary

AEGL -1 VALUES

Data were insufficient for deriving AGEL-1 values for n-hexane, so no values are recommended.

AEGL-2 VALUES

10 min 30 min 1 h 4 h 8 h
4,000 ppma (14,000 mg/m3) 2,900 ppma (10,000 mg/m3) 2,900 ppma (10,000 mg/m3) 2,900 ppma (10,000 mg/m3) 2,900 ppma (10,000 mg/m3)
Data adequacy: Data are not available to define the concentration-response curve for n-hexane. A steep concentration-response relationship is observed for butane, a structural analog of n-hexane and CNS depressant (NRC 2012), so a similar relationship is expected for n-hexane. For chemicals with a steep concentration-response curve, AEGL-2 values may be derived by reducing AEGL-3 values by one-third (NRC 2001). Therefore, AEGL-2 for values n-hexane were calculated by dividing the AEGL-3 values by 3.

aThe AEGL-2 value is higher than 10% of the lower explosive limit of n-hexane in air of 1.1% (11,000 ppm). Therefore, safety considerations against the hazard of explosion must be taken into account.

AEGL-3 VALUES

10 min 30 min 1 h 4 h 8 h
See belowa See belowb See belowb See belowb See belowb
Key reference: Raje, R.R., M. Greening, and M.T. Fine. 1984. Blood n hexane concentration following acute inhalation exposure in rats. Res. Commun. Chem. Pathol. Pharmacol. 46(2):297–300.
Test species/Strain/Number: Rat, Sprague-Dawely, groups of 4 male
Exposure route/Concentrations/Durations: Inhalation, 86,222 ppm for 10, 15, 20, 25, or 30 min.
Effects:
   Duration (min)
Effects
10 No effects
15 No effects
20 No effects
25 Ataxia, no deaths
30 Ataxia, no deaths


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