2001, 2003). In the absence of data on effects of density on population growth and for screening-level assessments, it is reasonable to use density-independent models. Such models often use population growth rate as the main result, although if the models are stochastic, they can also be used to estimate population viability (the probability of population decline or extinction over a specified period). Although density-independent models make a number of assumptions and leave out important aspects of population dynamics, their results are more relevant for assessing pesticide effects on species than the results of models that assess pesticide effects only on individual organisms.

If there is evidence that survival or reproduction changes as a function of population density, it is important to incorporate density dependence into a model. That a species is rare or has been in decline does not necessarily mean that its dynamics are not density-dependent. For example, if the species has been declining because of habitat loss, its dynamics are probably density-dependent. In addition, species that have declined to very low abundances might be subject to depensation or inverse density dependence, which is the reduction in survival or fecundity that occurs at low density and accelerates the species’ decline and which is commonly referred to as Allee effects (Courchamp et al. 2008).

Incorporating density dependence into a model of a population whose vital rates (survival or fecundity) might be affected by pesticide exposure presents challenges (Moe 2007). For example, the pesticide exposure might reduce the growth rate of the population by the same amount regardless of population size. Those conditions would make the density-dependence functions of baseline and effects models (population models with and without pesticide exposure) have the same shape (Figure 4-1A). In other cases, the pesticide effects on the growth rate of the population might be stronger in large populations (Figure 4-1B) and result in more-than-additive (synergistic) effects, or the pesticide effects might be stronger in small populations (Figure 4-1C) and result in less-than-additive (antagonistic) effects (see, for example, Forbes et al. 2001; Moe 2007). Thus, pesticide exposure might reduce the carrying capacity (or equilibrium population size) directly (by reducing survival and fecundity at all densities) or indirectly (by, for example, reducing abundance of species on which the species of interest preys). Whether the effect will be additive, synergistic, or antagonistic depends on several factors, including which life-history stages are affected by toxicity and density dependence (Forbes et al. 2001). The committee concludes that it is not accurate to assume that mortality due to pesticide exposure will be compensated for by density dependence; it is likely that such exposure will decrease the growth rate of a population at all densities and generally depress the population growth-density curve as depicted in Figure 4-1.

MIXTURES

Effects analysis requires knowledge or judgment of the adverse effects associated with individual chemicals or chemical combinations at concentrations



The National Academies | 500 Fifth St. N.W. | Washington, D.C. 20001
Copyright © National Academy of Sciences. All rights reserved.
Terms of Use and Privacy Statement