TABLE 4-1 Example Dataset Used to Assess Exposure to and Effects of Cypermethrin, in Mixture with Several Other Chemicals, on the Sockeye Salmon, Oncorhynchus nerka

1 2 3 4 5 6 7 8 9
Chemical Formulation (%) Tank (ppm) Environment (ppb) Final Exposure Concentration (ppb) Similar-Actinga K Values EC50 (ppb) Slope
Formulationb
Cypermethrin 0.05 250 0.01 0.015 a 5.0 14
PBO 1.0 5,000 0.2 0.205 Cyper: 1.0c Delta: 1.0c 10,000 5.0
Tank
Deltamethrin 100 0.004 0.004 a 3.1 15
Polysorbate 20 10,000 0.40 0.40 b 25,000 2.3
Epoxisoy 5,000 0.20 0.20 75,000 3.3
Environment
Nonylphenol 0.001 0.001 b,c 1,500 5.7
Ethinyl estradiol 0.05 0.05 c 1,400 6.1
Caffeine 500 500 33,000 3.9
Acetaminophen 0.01 0.01 100 6.3
PBO 0.005
Cypermethrin 0.005

aChemicals that act similarly are assigned the same letter.

bFormulations can be evaluated for the potential contribution of inerts as described in the section “Formulation Toxicity.”

cK values of 1.0 were assigned to the synergist PBO because the environmental exposure concentration of PBO in this exercise was considered to be below the interaction threshold.



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