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Directed Evolution for Development and Production of Bioactive Agents: A Meeting Summary (2013)

Chapter: Appendix A--Workshop Presentations and Participants

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Suggested Citation:"Appendix A--Workshop Presentations and Participants." National Research Council. 2013. Directed Evolution for Development and Production of Bioactive Agents: A Meeting Summary. Washington, DC: The National Academies Press. doi: 10.17226/18354.
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Appendix A
Workshop Presentations and Participants

PRESENTATIONS

Directed Evolution for Development and Production of Bioactive Agents
February 21-22, 2013
Washington, D.C.

Protein Switches and the Genetic Code
Marc Ostermeier, Professor and Vice Chair, Chemical and Biological Engineering
Johns Hopkins University

Directed Evolution of New Viruses for Gene Therapy
David Schaffer, Professor of Chemical and Biomolecular Engineering, Bioengineering, and Neuroscience
University of California, Berkeley

Expanding the Synthetic Capabilities of Yeast
Virginia W. Cornish, Helena Rubinstein Professor, Departments of Chemistry and Systems Biology
Columbia University

One Handful of Soil: 10,000,000,000 Microbes, 100,000 Different Species
Michael Fischbach, Assistant Professor, Department of Bioengineering and Therapeutic Sciences
University of California, San Francisco

Digital Chemistry: The Fabrication and Application of Ordered Molecular Arrays
Neal Woodbury, Co-Director of the Center for Innovations in Medicine, Professor of Chemistry and Biochemistry
Arizona State University

Cell-Penetrating Mini-Proteins
Gregory L. Verdine, Erving Professor of Chemistry
Harvard University

PARTICIPANTS

Committee

Mikhail Shapiro, University of California, Berkeley

Suggested Citation:"Appendix A--Workshop Presentations and Participants." National Research Council. 2013. Directed Evolution for Development and Production of Bioactive Agents: A Meeting Summary. Washington, DC: The National Academies Press. doi: 10.17226/18354.
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Speakers

Virginia W. Cornish, Columbia University

Michael Fischbach, University of California, San Francisco

Marc Ostermeier, Johns Hopkins University

David Schaffer, University of California, Berkeley

Gregory L. Verdine, Harvard University

Neal Woodbury, Arizona State University

Staff

Terry Jaggers, Board Director

Daniel Talmage, Study Director

Dionna Ali, Senior Program Assistant

Agencies Represented

Defense Advanced Research Projects Agency

Defense Intelligence Agency

Suggested Citation:"Appendix A--Workshop Presentations and Participants." National Research Council. 2013. Directed Evolution for Development and Production of Bioactive Agents: A Meeting Summary. Washington, DC: The National Academies Press. doi: 10.17226/18354.
×
Page 15
Suggested Citation:"Appendix A--Workshop Presentations and Participants." National Research Council. 2013. Directed Evolution for Development and Production of Bioactive Agents: A Meeting Summary. Washington, DC: The National Academies Press. doi: 10.17226/18354.
×
Page 16
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In 2012, the Defense Intelligence Agency (DIA) approached the National Research Council and asked that a committee be formed to develop a list of workshop topics to explore the impact of emerging science and technology. One topic that came out of that list was directed evolution for development and production of bioactive agents. This workshop was held on February 21-22, 2013.

Directed Evolution for Development and Production of Bioactive Agents explains the objectives of the workshop, which were to explore the potential use of directed evolution1 for military science and technology. Understanding the current research in this area, and the potential opportunities for U.S. adversaries to use this research, might allow the DIA to advise U.S. policy makers in an appropriate and timely manner. The workshop featured invited presentations and discussions that aimed to:

-Inform the U.S. intelligence community of the current status of directed evolution technology and related research, and

-Discuss possible approaches involving directed evolution that might be used by an adversary to develop toxic biological agents that could pose a threat to the United States or its allies, and how they could be identified.

Members of the Committee on Science and Technology for Defense Warning planned the agenda for the workshop, selected the presenters, and helped moderate discussions in which meeting participants probed issues of national security related to directed evolution in an effort to gain an understanding of potential vulnerabilities. Experts were invited from the areas of directed evolution, biosynthesis, detection, and biological agents.

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