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Appendix A Workshop Presentations and Participants PRESENTATIONS Directed Evolution for Development and Production of Bioactive Agents February 21-22, 2013 Washington, D.C. Protein Switches and the Genetic Code Marc Ostermeier, Professor and Vice Chair, Chemical and Biological Engineering Johns Hopkins University Directed Evolution of New Viruses for Gene Therapy David Schaffer, Professor of Chemical and Biomolecular Engineering, Bioengineering, and Neuroscience University of California, Berkeley Expanding the Synthetic Capabilities of Yeast Virginia W. Cornish, Helena Rubinstein Professor, Departments of Chemistry and Systems Biology Columbia University One Handful of Soil: 10,000,000,000 Microbes, 100,000 Different Species Michael Fischbach, Assistant Professor, Department of Bioengineering and Therapeutic Sciences University of California, San Francisco Digital Chemistry: The Fabrication and Application of Ordered Molecular Arrays Neal Woodbury, Co-Director of the Center for Innovations in Medicine, Professor of Chemistry and Biochemistry Arizona State University Cell-Penetrating Mini-Proteins Gregory L. Verdine, Erving Professor of Chemistry Harvard University PARTICIPANTS Committee Mikhail Shapiro, University of California, Berkeley 15
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16 DIRECTED EVOLUTION FOR DEVELOPMENT AND PRODUCTION OF BIOACTIVE AGENTS Speakers Virginia W. Cornish, Columbia University Michael Fischbach, University of California, San Francisco Marc Ostermeier, Johns Hopkins University David Schaffer, University of California, Berkeley Gregory L. Verdine, Harvard University Neal Woodbury, Arizona State University Staff Terry Jaggers, Board Director Daniel Talmage, Study Director Dionna Ali, Senior Program Assistant Agencies Represented Defense Advanced Research Projects Agency Defense Intelligence Agency