Committee on Problems of Alcohol: A Report of Its Activities From 1949 to 1955, the Research Work It Has Supported and the Place of This Work in the Field of Alcoholism (1956)

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-21- . , Appendix A ... ..... , . .; List of Grants •COM•IITTEE.ON PROBLEMS OF ALCOHOL Grantee Diethelm, Oskar Institution - »•• •! , Cornell University Medical College - New York Hospital Ellis, Fred W. School of Medicine Title of Research Research on the etiology of chronic alcoholisnu Pharmacologically active substances found in the blood of alcoholic subjects. The possible relationship University of Worth Carolina between adrenal cortical .•••' • • .. function and experimental alcoholism. Qnerson, The University of Texas G. A8 • Medical Branch Fields, New York School of Education Morey B. and «•«•'* .i • Nash, Jay B. Forbes, Medical College of Virginia J. C. Greenberg, Yale University Leon A. Grenell, University of Maryland Robert G» Medical School Factors affecting voluntary intake of alcohol in experi- mental animals* Grant for the establishment of a course in alcohol educa- tion, to run for a 3-year period* The effect of ascorbic acid intake on (a) the concentra- tion of ascorbic acid and cholesterol in the adrenal glands of the guinea pig following a state of acute alcoholic intoxication, and (b) the 1050 of ethyl alco- hol for e^iinea pigs . The role of pantothenic acid and vitamin C in alcoholism. The effects of small and moderate amounts of alcohol as influenced by accommoda- tion and oxygen tension. The effects of alcohol on fundamental properties of the nervous system. Effects of alcohols on cere- bral neurons. Year 1947-1951* 1952-1953 1955-1956 1953-1955 1949-1951* 1951-1952 1952-1954 1955-1956 1951-1955 1955-1956 * Support initiated under Research Council on Problems of Alcohol.

Grantee Hine, Charles "Henri Hoick, Harald Hulpieu, Institution School of Medicine ;Ui4ye£3iiy of California Co^ege of Pharmacy University of Nebraska •'•:.'..ty.• "•;.£:'•• I1..•. ?I:.v.S'-• • •: : f. ;••' :'.•: ;:v•••••'; rov-.-. •.':.-..;. ;:•'.'.,.'•'•• .- V- £«?%•.. ".i ;' ••;: j School of Medicine " ••, . Indiana University - . s. .- **•' ~f -i; ;;.••:••:.• . . •.• / ..:••::••± .K. .:/i..: .'••:• ' / '.•.v.' '.T^: iroi.;..n./; «.i.'. ••.••».• ^l.i Year 1952-1956 '/«. .q.ollege of .South.... Fredrick W. •Carolina '. '' ''"''' •••».• X' '•"*•• (''• ri••. .""' Knoefel, Peter K. Mallov, Samuel School of Medicine University of;Louisville The Research Foundation of'State University of New York . .,;.•• Najjar, Victor A* Johns Hopkins University ••••>•• • Title of Research • The metabolism of ethanol in vivp.and in.vitro, .'fee;' inhibitory' effect 'of.' '.: "tetraethylthiuram disulf ide (Antabuse) upon reproduction of the albino rat. Pharmacological comparison of agents which have. been r.eported $6"increase' the!' toxicity of alcoholo Studies on an Antabuse- alcohol .reaction produced by animal charcoal followed by the ingestion of alcohol, The role of catalase in . ethanol metabolism. ' The effects of alcohol de- hydrogenase and catalase levels on the ethanol oxi- dizing capacity of the liver. The changes in water and '1953-1956 electrolytes in experimental alcoholism, The production of fatty 1953-1955 livers in rats by chronic ethanol intoxication, and the role of lipotropic agents. The role of hormones in the 1955-1956 production of fatty infiltra- t; tion of the liver in rats by means of acute ethanol intoxi- cation. The, identification and puri- 1952-1953 fication of the enzymes re- {. sponsible for alcohol utiliza- tion and study of their bio- chemical characteristics. 1951-1953 1953-1956 1954-1955 1955-1956

-23- Grantee NaJJar, Victor A, (Cont'd) Institution Johns Hopkins University Hacker, Efraim Richter, Curt P, Sapirstein, Leo A. Smith, James J. Swinyard, Chester A, Voegtlin, Walter L. Walker, A. Earl Williams, Roger J0 Zarrow, M. X. School of Medicine Yale University Johns Hopkins Medical School Title of Research The effect of alcohol iiv- gestion on the dehydrogenase system in tissues „ The effect of alcohol on the antibody to alcohol dehydro- genase, A study of the property of the yeast alcohol dehydro- genase enzyme* The experimental production of a craving for alcohol and alcoholic beverages. The Ohio State University Natriuretic effects of alco- Medical School hoi, College of Medicine New York University College of Medicine University of Utah University of Washington Johns Hopkins Medical School Biochemical and endocri- nologic aspects of alco- holism. Tissue tolerance to alco holo Studies on the allergic factor in chronic alco- holism. Year 1953-1954 1954-1955 1953-1954 1951-1955 1955-1956 1948-1951 1954-1956 1948-1949 Biochemical Institute University of Texas Purdue University The effect of alcohol, par- 1951-1953 enterally administered, upon the vascular system of the brain; the effect of alcohol upon cerebral vascular perme- ability; and the pathogenesis of the "wet brain" seen in some alcoholics and its rela- tion to cerebral edema. Metabolic factors in the eti- 1947-1949* ology of alcoholism, The relationship of the 1951-1953 adrenal gland to alcoholism. The role of the hormones in 1953-1954 alcoholism, Support initiated under Research Council on Problems of Alcohol«

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-24- REFSRENCES • 1. Allan, F. D, and Swinyard, C. A.: Evaluatiqn of Tissue Tolerance te Alcoh6l by Alterations in the Electroshock Seizure Threshold in Rats, Anat. Rec, 103_:3, 1949V '; •.;. ."• 2, Bales, R. P.: Cultural Differences in Rates of Alcoholism, Quart. J. Stud. Ale. 6:480-499, 1946. 3« Cowen, J.: Treatment by Enforced Abstinence, Quart* J.. Stud. Ale. 2£:413-23, 1954.^ .•.;:..; V;' .': 4. Fleetwood, M. F, and Diethelm, 0»: Emotions and Biochemical Findings in Alcoholism, Am. J. Psychiat. 108:433-438, 1951. • * ' *. . ' i '•.-•*— 5» Fleetwood, M. F.t 3iochemical Experimental Investigations of Emotions and Chronic Alcoholism, Etiology of Chronic Alcoholism, ed. by 0. Diethelm, Springfield, Illinois, C C Thomas, 1955, pp. 43-109* ''••-.• ,••" , t • '• 6. Forbes, J. C. and Duncan, G. Mr: Effect of Vitamin C Intake on the Adrenal Response of Rats and Guinea Pigs tp Alcohol Administration, Quart. J. Stud. Ale. 14j22-27, 1953. 7. . Forbes, J. C. and Duncan, G, M»: Effect pf Repeated Alcohol Administra- tion on Adrenal Ascorbic Acid and on Development of Survey in the Guinea Pig, Quart. J. Stud. Ale. 1^:540-544, 1953. • * • • ' » 8» Gibbins, R. J0: Chronic Alcoholism, Brookside Monograph No. 1, Alco- holism Research Foundation, Ontario, 1953» 9. Gibbins, R. J,: Alcoholism in Ontario, Quart. J. Stud, Ale. 15;47-62, 1954. 10. Goodman, L. S, and Gilman, A.: The Pharmacological Basis of Therapeutics, 2nd Ed. New York, The MacMillan Co., 1955c. 11. Haggard, H. W. and Jellinek, E. M.:. Alcohol Explored, Garden City, New ;. York, Doubleday, Doran'and Coe, Inc., 1942. 12. Hoff, E, and HcKeown, C.: An Evaluation of the Use of TETO in the •• Treatment of 560 Cases of Alcohol Addictions, Am. J8 Psychiat« 109:670-673, 1953. 13e Horsey, W. J.: The Effect of Acute Alcoholic Intoxication on the Blood- Brain Barrier, J, Neuropath, and Exp. Neurol. 12:368-372, 1953. 14. Horsey, W. J, and Akert, K.: The Influence of Ethyl Alcohol on the Spontaneous Electrical Activity of the Cerebral Cortex and Subcortical Structures of the Cat, Quart. J. Stud. Ale. 1^:363-377, 1953.