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Suggested Citation:"References." Institute of Medicine. 2014. Improving the Efficiency and Effectiveness of Genomic Science Translation: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/18549.
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References

Abrahams, B. S., and D. H. Geschwind. 2008. Advances in autism genetics: On the threshold of a new neurobiology. Nat Rev Genet 9(5):341–355.

Anglesio, M. S., S. Kommoss, M. C. Tolcher, B. Clarke, L. Galletta, H. Porter, S. Damaraju, S. Fereday, B. J. Winterhoff, S. E. Kalloger, J. Senz, W. Yang, H. Steed, G. Allo, S. Ferguson, P. Shaw, A. Teoman, J. J. Garcia, J. K. Schoolmeester, J. Bakkum-Gamez, A. V. Tinker, D. D. Bowtell, D. G. Huntsman, C. B. Gilks, and J. N. McAlpine. 2013. Molecular characterization of mucinous ovarian tumours supports a stratified treatment approach with HER2 targeting in 19% of carcinomas. J Pathol 229(1):111–120.

Baker, M. 2012. Gene data to hit milestone. Nature 487(7407):282–283.

Capdeville, R., E. Buchdunger, J. Zimmermann, and A. Matter. 2002. Glivec (sti571, imatinib), a rationally developed, targeted anticancer drug. Nat Rev Drug Discov 1(7):493–502.

CDC (Centers for Disease Control and Prevention). 2011. National diabetes fact sheet: National estimates and general information on diabetes and prediabetes in the United States, 2011. Atlanta, GA: Centers for Disease Control and Prevention, U.S. Department of Health and Human Services.

Gandhi, L., and P. A. Janne. 2012. Crizotinib for ALK-rearranged non-small cell lung cancer: A new targeted therapy for a new target. Clin Cancer Res 18(14):3737–3742.

Gneezy, U., J. A. List, and G. Wu. 2006. The uncertainty effect: When a risky prospect is valued less than its worst outcome. Q J Econ 121:1283–1309.

Grimm, T., W. Kress, G. Meng, and C. R. Muller. 2012. Risk assessment and genetic counseling in families with Duchenne muscular dystrophy. Acta Myol 31(3):179–183.

Harrison, K. D., N. S. Kadaba, R. B. Kelly, and D. Crawford. 2012. Building a life sciences innovation ecosystem. Sci Transl Med 4(157):157fs137.

Holy, T. E., and Z. Guo. 2005. Ultrasonic songs of male mice. PLoS Biol 3(12):e386.

IOM (Institute of Medicine). 2012. Evolution of translational omics: Lessons learned and the path forward. Washington, DC: The National Academies Press.

Suggested Citation:"References." Institute of Medicine. 2014. Improving the Efficiency and Effectiveness of Genomic Science Translation: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/18549.
×

Iossifov, I., M. Ronemus, D. Levy, Z. Wang, I. Hakker, J. Rosenbaum, B. Yamrom, Y. H. Lee, G. Narzisi, A. Leotta, J. Kendall, E. Grabowska, B. Ma, S. Marks, L. Rodgers, A. Stepansky, J. Troge, P. Andrews, M. Bekritsky, K. Pradhan, E. Ghiban, M. Kramer, J. Parla, R. Demeter, L. L. Fulton, R. S. Fulton, V. J. Magrini, K. Ye, J. C. Darnell, R. B. Darnell, E. R. Mardis, R. K. Wilson, M. C. Schatz, W. R. McCombie, and M. Wigler. 2012. De novo gene disruptions in children on the autistic spectrum. Neuron 74(2):285–299.

Kodama, K., M. Horikoshi, K. Toda, S. Yamada, K. Hara, J. Irie, M. Sirota, A. A. Morgan, R. Chen, H. Ohtsu, S. Maeda, T. Kadowaki, and A. J. Butte. 2012. Expression-based genome-wide association study links the receptor CD44 in adipose tissue with type 2 diabetes. Proc Natl Acad Sci USA 109(18):7049–7054.

Li, H., K. A. Robinson, B. Anton, I. J. Saldanha, and P. W. Ladenson. 2011. Cost-effectiveness of a novel molecular test for cytologically indeterminate thyroid nodules. J Clin Endocrinol Metab 96(11): E1719–E1726.

Liew, W. K., and P. B. Kang. 2013. Recent developments in the treatment of Duchenne muscular dystrophy and spinal muscular atrophy. Ther Adv Neurol Disord 6(3):147–160.

Mankoff, S. P., C. Brander, S. Ferrone, and F. M. Marincola. 2004. Lost in translation: Obstacles to translational medicine. J Transl Med 2(1):14–18.

McAlpine, J. N., K. C. Wiegand, R. Vang, B. M. Ronnett, A. Adamiak, M. Kobel, S. E. Kalloger, K. D. Swenerton, D. G. Huntsman, C. B. Gilks, and D. M. Miller. 2009. Her2 overexpression and amplification is present in a subset of ovarian mucinous carcinomas and can be targeted with trastuzumab therapy. BMC Cancer 9:433.

NRC (National Research Council). 2011. Toward precision medicine: Building a knowledge network for biomedical research and a new taxonomy of disease. Washington, DC: The National Academies Press.

O’Roak, B. J., L. Vives, S. Girirajan, E. Karakoc, N. Krumm, B. P. Coe, R. Levy, A. Ko, C. Lee, J. D. Smith, E. H. Turner, I. B. Stanaway, B. Vernot, M. Malig, C. Baker, B. Reilly, J. M. Akey, E. Borenstein, M. J. Rieder, D. A. Nickerson, R. Bernier, J. Shendure, and E. E. Eichler. 2012. Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations. Nature 485(7397):246–250.

PCAST (President’s Council of Advisors on Science and Technology). 2012. Report to the President on propelling innovation in drug discovery, development, and evaluation. Washington, DC: Executive Office of the President.

Sanders, S. J., M. T. Murtha, A. R. Gupta, J. D. Murdoch, M. J. Raubeson, A. J. Willsey, A. G. Ercan-Sencicek, N. M. DiLullo, N. N. Parikshak, J. L. Stein, M. F. Walker, G. T. Ober, N. A. Teran, Y. Song, P. El-Fishawy, R. C. Murtha, M. Choi, J. D. Overton, R. D. Bjornson, N. J. Carriero, K. A. Meyer, K. Bilguvar, S. M. Mane, N. Sestan, R. P. Lifton, M. Gunel, K. Roeder, D. H. Geschwind, B. Devlin, and M. W. State. 2012. De novo mutations revealed by whole-exome sequencing are strongly associated with autism. Nature 485(7397):237–241.

Waldrop, M. M. 2011. Research at Janelia: Life on the farm. Five years in, has a lofty experiment in interdisciplinary research paid off? Nature 479:284–286.

Suggested Citation:"References." Institute of Medicine. 2014. Improving the Efficiency and Effectiveness of Genomic Science Translation: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/18549.
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Page 45
Suggested Citation:"References." Institute of Medicine. 2014. Improving the Efficiency and Effectiveness of Genomic Science Translation: Workshop Summary. Washington, DC: The National Academies Press. doi: 10.17226/18549.
×
Page 46
Next: Appendix A: Workshop Agenda »
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The process for translating basic science discoveries into clinical applications has historically involved a linear and lengthy progression from initial discovery to preclinical testing, regulatory evaluation and approval, and, finally, use in clinical practice. The low rate of translation from basic science to clinical application has been a source of frustration for many scientists, clinicians, investors, policy makers, and patients who hoped that investments in research would result in improved products and processes for patients. Some feel that the anticipated deliverables from the Human Genome Project have not yet materialized, and although understanding of human health and disease biology has increased, there has not been a concomitant increase in the number of approved drugs for patients over the past 10 years.

Improving the Efficiency and Effectiveness of Genomic Science Translation is the summary of a workshop convened by the Institute of Medicine Roundtable on Translating Genomic-Based Research for Health in December 2012 to explore ways to improve the efficiency and effectiveness of the translation of genomic science to clinical practice. The workshop convened academic researchers, industry representatives, policy makers, and patient advocates to explore obstacles to the translation of research findings to clinical practice and to identify opportunities to support improvement of the early stages of the process for translation of genetic discoveries. This report discusses the realignment of academic incentives, the detection of innovative ways to fund translational research, and the generation or identification of alternative models that accurately reflect human biology or disease to provide opportunities to work across sectors to advance the translation of genomic discoveries.

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