measurements in the testing laboratory and the quantitative reproducibility of the population measurements in the laboratory that generated the databank. In addition, the matching rule should reflect that one is making intergel comparisons, which are typically less precise than intra-gel comparisons.
The above approach is sometimes referred to as ''floating bins," in that one counts the alleles that fall into a "bin" centered on the allele of interest. Most forensic laboratories in this country use the slightly different approach of "fixed bins":22 One first aggregates alleles into a predetermined set of bins. Given an allele in a forensic case, one must then compute its frequency by adding the frequencies of all the bins that contain any alleles that fall within the window specified by the laboratory's forensic matching rule. (All bin frequencies must be added; it is not enough to take the largest of the bin frequencies.) This fixed-bin approach is acceptable and might be more convenient in some settings, because examiners need only consult a short table of bin frequencies, rather than search an entire databank.
Because of the laws of Mendelian inheritance, the genotypes of biological relatives are much more similar than those of random individuals. Parent and child share exactly one identical allele at every locus, sibs share an average of one identical allele per locus, and grandparent and grandchild share an average of 0.5 identical allele per locus. (Here, identical refers to identity by descent from a common ancestor. Relatives can share additional alleles simply by chance.) These facts have important consequences for DNA typing:
The genetic correlation between relatives makes it possible to carry out parentage and grandparentage testing. Paternity testing with DNA typing is already an active industry in the United States, and grandmaternity testing (with mitochondrial DNA, as well as nuclear genes) has been used in Argentina to reunite families with children who were abducted during the military dictatorship in the 1970s.23,24 Relatedness testing involves a question analogous to that asked in identity testing: What is the chance that a randomly chosen person in the population would show the degree of relatedness expected of a relative? The same basic methods of population genetics apply, as discussed earlier.
The ability to recognize relatedness poses a novel privacy issue for DNA databanks. Many states are starting to compile databanks that record patterns of DNA from convicted criminals, but not from other citizens, with the hope of identifying recidivists. When a biological sample is found at