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CONTROL OF RABIES Subcommittee on Rabies Committee on Animal Health Agricultural Board National Research Council NATIONAL ACADEMY OF SCIENCES WASHINGTON, D.C. 1973 NAS-NAE JUN1 1973 LIBRARY
NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, acting in behalf of the National Academy of Sciences. Such approval reflects the Board's judgment that the project is of national importance and appropriate with respect to both the purposes and resources of the National Research Council. The members of the committee selected to undertake this project and prepare this report were chosen for recognized scholarly competence and with due consideration for the balance of disciplines appropriate to the project. Responsibility for the detailed aspects of this report rests with that committee. Each report issuing from a study committee of the National Research Council is reviewed by an independent group of qualified individuals according to procedures established and monitored by the Report Review Committee of the National Academy of Sciences. Distri- bution of the report is approved, by the President of the Academy, upon satisfactory com- pletion of the review process. This study was partially supported by the U.S. Department of Agriculture Available from Printing and Publishing Office, National Academy of Sciences 2101 Constitution Avenue, Washington, D.C. 20418 2.. oo LIBRARY OF CONGRESS CATALOGING IN PUBLICATION DATA National Research Council. Subcommittee on Rabies. Control of rabies. Bibliography: p. 1. Rabies-Preventive innoculation. I. Title. [DNLM: 1. Rabies-Prevention and control. WC550 N277c 1973] RA644.R3N37 614.5'63 73-7802 ISBN 0-309-02124-3 Printed in the United States of America Order from National Technicaf Information Service, Springfield, Va. 22151
Preface In the 26 years since the publication of Rabies and its Control, there has been important progress in our understanding of the disease and the virus. More effective vaccines are now available, the epidemiologic patterns of the disease have become clearer, and diagnostic techniques are more sure. This report deals with the pathogenesis of the disease, with virus- wildlife interactions, and with vaccines and regulatory aspects. In preparing it, the subcommittee has had the benefit of views from the following consultants representing a variety of disciplines and back- grounds: Donald Balser, Albert L. Brown, H. R. Fischman, John M. Hejl, George L. Humphrey, Edward Phillips, Robert E. Shope, and W. G. Winkler. Hi
COMMITTEE ON ANIMAL HEALTH CHARLES E. CORNELIUS, Chairman SIDNEY EWING N. S. FECHHEIMER ROBERT P. HANSON NELS KONNERUP PAUL M.NEWBERNE A. DONALD RANKIN RICHARD A. TJALMA KENNETH DUANE WEIDE SUBCOMMITTEE ON RABIES PETER c. KENNEDY,Chairman VICTOR J. CABASSO DAVID E. DAVIS R. K. SIKES CHARLES J. YORK
Contents THE DISEASE 1 Pathogenesis Epidemiology CONTROL 5 Vaccines Licensure and Testing; Development and Marketing; Use Population Control Terrestrial Mammals; Bats; Domestic Animals Quarantine and Postexposure Practices International Quarantine; Interstate Quarantine; Postexposure Practices Prevention of Rabies in Man Regulatory Aspects of Control RECOMMENDATIONS 20 REFERENCES 23 APPENDIX-Rabies Vaccines 25
