B

Workshop on Key Challenges in the Implementation of Convergence: Agenda and Participants

AGENDA

September 16

8:00

Welcome
Chair: Joseph DeSimone (NAS, NAE), Committee Chair, Frank Hawkins Kenan Institute of Private Enterprise, University of North Carolina, and North Carolina State University

  • Overview of the background and goals of the meeting: Joseph DeSimone
  • Welcome on behalf of the National Academies:

    • Ralph Cicerone (NAS), President, National Academy of Sciences
    • C. D. Mote, Jr. (NAE), President, National Academy of Engineering
    • Harvey Fineberg (IOM), President, Institute of Medicine (by video)
  • How the goals of convergence complement OSTP priorities and activities: White House Office of Science and Technology Policy (OSTP)


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B Workshop on Key Challenges in the Implementation of Convergence: Agenda and Participants AGENDA September 16 8:00 Welcome  Chair: Joseph DeSimone (NAS, NAE), Committee Chair, Frank Hawkins Kenan Institute of Private Enterprise, University of North Carolina, and North Carolina State University •  verview of the background and goals of the O meeting: Joseph DeSimone • Welcome on behalf of the National Academies: o  alph Cicerone (NAS), President, National Academy of R Sciences o  . D. Mote, Jr. (NAE), President, National Academy of C Engineering o  arvey Fineberg (IOM), President, Institute of H Medicine (by video) •  ow the goals of convergence complement OSTP H priorities and activities: White House Office of Science and Technology Policy (OSTP) 123

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124 APPENDIX B 8:30 Recognizing Emerging Areas of Science at the Convergence Interface  Chair: Nicholas Peppas (NAE, IOM), University of Texas at Austin Session goal: What can convergence achieve and what are selected examples of science with exciting implications that cannot be achieved without a convergence mindset and approach? •  hillip Sharp (NAS, IOM), Massachusetts Institute of P Technology 9:00 Establishing Background and Introduction to the Examples of Convergent and Transdisciplinary Science Chair: Hannah Valantine, Stanford University Session goal: What is the existing research base on how to foster and measure the success of convergent, transdisciplinary, and/or team-science-based research? •  verview of NRC Study of the Science of Team O Science: Hannah Valantine, Stanford University •  eview of the committee’s definition of convergence: R Julie Thompson Klein, Wayne State University and David Roessner, SRI International 9:30 Break Fostering Convergence in the Real World How can the goals of convergence translate into practical results; that is, what have groups and organizations specifically done to support and foster convergence-enabled science? What has worked well and what has not worked as well? Speakers representing several different perspectives will provide brief snapshots of what they did, what challenges they faced, and what they learned. 9:45 The ecosystem of convergent research and innovation in the life sciences: Cherry Murray (NAS, NAE), Harvard University 10:00 Key Organizational Structures and Needs  Chair: Timothy Galitski, EMD Millipore Corporation and Institute for Systems Biology Session goal: Speakers in this session will particularly highlight factors in the successful implementation of

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APPENDIX B 125 convergent research such as organizational policies and support structures, strategies to address differences in research practices from bringing diverse communities together, and physical and technical components. •  arla Shatz (NAS, IOM), Bio-X, Stanford University C •  nna Barker, Transformative Healthcare Networks and A Complex Adaptive Systems Network, Arizona State University •  usan Singer, Carleton College and National Science S Foundation 11:00 Faculty Issues  Chair: Cato Laurencin (NAE, IOM), University of Connecticut Session goal: Speakers in this session will particularly focus on issues such as institutional rewards systems for convergence research and hiring, retention, promotion, and professional development of faculty •  ernando Martinez, Bio5 Institute, University of Arizona F •  onald Ingber (IOM), Wyss Institute for Biologically D Inspired Engineering, Harvard University •  erald Rubin, (NAS, IOM), Janelia Farm Research G Campus, Howard Hughes Medical Institute 12:00 Working Lunch and Activity If you could recommend one action each of the following actors could take that would best facilitate convergent research, what action would that be? Please try to identify a recommended action for at least two of the following categories. Write your answers on the provided post-it notes and affix them to the space beneath the name of the actor: a)  nstitutions (e.g., universities, professional I associations, nonprofits) b) Units/Departments c) Principal Investigators/Team Leaders d) Educators e) Postdoctoral Fellows and Students f) Funding Agencies g) Journal Editors 1:00 Challenges of Convergent Thinking and Innovation  Chair: Carol Folt, University of North Carolina, Chapel Hill •  runava Majumdar (NAE), Google A

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126 APPENDIX B Fostering Convergence in the Real World, continued 1:30 Education and Training Chair: Lynne Regan, Yale University Session goal: Speakers in this session will highlight issues surrounding the education and training of students. Issues might include ensuring students get the breadth of training and experience to work in a multidisciplinary setting but sufficient subject expertise for a major; how to issue degrees that span multiple departments or institutions; or other areas. •  aterina V. Thompson, University of Maryland College K Park •  imon Mochrie, Yale University S •  ndrea Stith, BioFrontiers Institute, University of A Colorado 2:30 Interinstitutional Arrangements and Partnerships Chair: Sharon Glotzer, University of Michigan Session goal: Speakers in this session will particularly discuss arrangements that span institutions. •  ruce Walker (IOM), Ragon Institute, Massachusetts B General Hospital, Massachusetts Institute of Technology, and Harvard University •  avid Canter, North Campus Research Complex, D University of Michigan •  egis Kelly, California Institute for Quantitative R Biosciences (QB3), University of California 3:30 Brief Break and Move to Small-Group Discussion Sections 3:45 Discussion Sessions Session goal: Participants will be asked to think about the examples and models presented in the workshop as well as their own experiences, and start drawing out lessons on what works in different circumstances. Are there common themes? Are there factors that affect which model(s) appear to work best in different settings or for different goals? Participants will be assigned to a group based on their preferences and in order to get a balanced distribution. Discussion sessions will be given questions to use as starting points.

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APPENDIX B 127 •  ROUP A: Key Organizational Structures and Needs G Chair: Robert Nerem (NAE, IOM), Georgia Institute of Technology Rapporteur: Adah Almutairi, University of California San Diego •  ROUP B: Faculty Issues G Chair: Carl Simon, University of Michigan Rapporteur: Joshua Kritzer, Tufts University •  ROUP C: Education and Training G Chair: Emery Brown (IOM), Massachusetts Institute of Technology Rapporteur: Jasmine Foo, University of Minnesota-Twin Cities •  ROUP D: Interinstitutional Arrangements and G Partnerships Chair: Matthew Tirrell (NAE), University of Chicago Rapporteur: Manu Platt, Georgia Institute of Technology and Emory University 5:30 Adjourn for Day Reception to follow September 17 8:15 Introduction to Day 2: Joseph DeSimone, Committee Chair 8:30 Feedback from the Breakout Groups Chair: Monica Olvera de la Cruz, Northwestern University Session goal: Breakout session rapporteurs will provide brief recaps of the key points from their group, followed by discussion. 9:30 Funding Models Chair: James Gentile, Hope College Session goal: Provide an opportunity for agencies and foundations to share how they think about this issue and what issues or challenges they face. •  on Lorsch, National Institute of General Medical J Sciences, National Institutes of Health

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128 APPENDIX B •  inah Singer, National Cancer Institute, National D Institutes of Health •  oann Roskoski, Directorate for Biological Sciences, J National Science Foundation •  aria Pellegrini, W.M. Keck Foundation M 10:30 Break 10:45 Plenary: Roadmap for the Future  Discussion Leaders: Susan Hockfield, Massachusetts Institute of Technology and Joseph DeSimone, Frank Hawkins Kenan Institute of Private Enterprise, University of North Carolina, and North Carolina State University Session goal: A facilitated discussion to draw out key messages and lessons learned from the workshop. 12:15 Concluding Remarks: Joseph DeSimone, Committee Chair 12:30 Workshop Adjourns

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APPENDIX B 129 PARTICIPANT LIST Margaret Ackerman Dennis Ausiello Assistant Professor Director, Center for Assessment Thayer School of Engineering Technology and Continuous Dartmouth College Health Jackson Professor of Clinical Adah Almutairi Medicine, Harvard Medical Associate Professor School Skaggs School of Pharmacy and Chief, Department of Medicine, Pharmaceutical Sciences Massachusetts General University of California, San Hospital Diego Randy Avent Joseph Alper Professor, Department of Consulting Science Writer Computer Science Associate Vice Chancellor for Adam Arkin Research Development Dean A. Richard Newton North Carolina State University Memorial Professor, Department of Bioengineering Roberto Barbero University of California, Berkeley AAAS Fellow Director, Physical Biosciences Technology and Innovation Division Division Lawrence Berkeley National Office of Science and Technology Laboratory Policy Executive Office of the President Amanda Arnold Senior Policy Advisor Anna Barker MIT Washington Office Professor and Director, Transformative Healthcare Ann Arvin Networks Vice Provost and Dean of Research Co-Director, Complex Adaptive Lucile Salter Packard Professor Systems Network of Pediatrics and Professor of Arizona State University Microbiology & Immunology Stanford University Cynthia Bauerle Assistant Director Undergraduate and Graduate Education Howard Hughes Medical Institute

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130 APPENDIX B Ann Beheler V. Celeste Carter Executive Director of Emerging Program Director Technology Grants Advanced Technological Collin College Education Program Directorate for Education & Rena Bizios Human Resources Peter T. Flawn Professor National Science Foundation Department of Biomedical Engineering Miyoung Chun University of Texas at San Antonio Executive Vice President of Science Programs Krastan Blagoev The Kavli Foundation Program Director, Physics of Living Systems Ralph Cicerone Directorate for Mathematical & President Physical Sciences National Academy of Sciences National Science Foundation Lee Ann Clements William B. Bonvillian Professor of Biology and Marine Director Science MIT Washington Office Chair, Division of Science and Mathematics Emery Brown Jacksonville University Professor of Computational Neuroscience and Health James Collins Sciences and Technology William F. Warren Distinguished Massachusetts Institute of Professor Technology Department of Biomedical Warren M. Zapol Professor of Engineering Anesthesia Boston University Harvard Medical School Clark Cooper David Canter Senior Advisor for Science Executive Director and Head of the Office of North Campus Research Complex Multidisciplinary Activities University of Michigan Directorate for Mathematical & Physical Sciences Ruben Carbonell National Science Foundation Director William R. Kenan, Jr. Institute for Engineering, Technology & Science North Carolina State University

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APPENDIX B 131 Joseph DeSimone Carol Folt Director, Frank Hawkins Kenan Chancellor Institute of Private Enterprise University of North Carolina, Chancellor’s Eminent Professor Chapel Hill of Chemistry, University of North Carolina (UNC) Jasmine Foo William R. Kenan Jr. Distinguished McKnight Land Grant Assistant Professor of Chemical Professor of Mathematics Engineering, NC State University of Minnesota-Twin University and of Chemistry, Cities UNC Cathy Fromen Raymond DuBois Graduate Student Executive Director Department of Chemical Biodesign Institute Engineering Arizona State University North Carolina State University Jennifer Elisseeff Timothy Galitski Jules Stein Professor Head of Science & Technology Department of Biomedical EMD Millipore Corporation Engineering and Wilmer Eye Affiliate Professor Institute Institute for Systems Biology Johns Hopkins University James Gentile Pelagie Favi Dean for the Natural and Applied Graduate Student Sciences Department of Materials Science Hope College and Engineering University of Tennessee Ronald Germain Chief, Lymphocyte Biology Harvey Fineberg Section President National Institute of Allergy and Institute of Medicine Infectious Diseases National Institutes of Health Michael Fisher Distinguished University Professor and Regents Professor Institute for Physical Science and Technology and Department of Physics University of Maryland

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132 APPENDIX B Sharon Glotzer Kathryn Hughes S. W. Churchill Collegiate Senior Program Officer Professor of Chemical Board on Chemical Sciences and Engineering Technology Professor of Materials Science & National Research Council Engineering Professor of Physics, Applied Lynn Hull Physics and Macromolecular AAAS Science and Technology Science & Engineering Policy Fellow University of Michigan Office of Cancer Nanotechnology Research Piotr Grodzinski National Cancer Institute Director, Office of Cancer National Institutes of Health Nanotechnology Research National Cancer Institute Donald Ingber National Institutes of Health Director, Wyss Institute for Biologically Inspired Xue Han Engineering Assistant Professor Judah Folkman Professor of Department of Biomedical Vascular Biology, Harvard Engineering Medical School & Boston Boston University Children’s Hospital Professor of Bioengineering William Harris Harvard University President and CEO Science Foundation Arizona Ravi Iyengar Professor and Chair, Department James Zachary Hilt of Pharmacology and Systems Associate Professor Therapeutics Department of Chemical Director, Experimental Engineering Therapeutics Institute University of Kentucky Icahn School of Medicine at Mount Sinai Margaret Hilton Senior Program Officer Thomas Kalil Board on Science Education Deputy Director for Technology National Research Council and Innovation Technology and Innovation Susan Hockfield Division Professor of Neuroscience and Office of Science and Technology President Emeritus Policy Massachusetts Institute of Executive Office of the President Technology

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APPENDIX B 133 Lydia Kavraki Jerry Lee Noah Harding Professor of Deputy Director Computer Science and Center for Strategic Scientific Bioengineering Initiatives Rice University National Cancer Institute National Institutes of Health Rusty Kelley Program Officer Jon R. Lorsch Burroughs Wellcome Fund Director National Institute of General Regis Kelly Medical Sciences Director National Institutes of Health California Institute for Quantitative Biosciences (QB3) Gesham Magombedze Postdoctoral Fellow Melissa Kinney National Institute for Graduate Student Mathematical and Biological Parker H. Petit Institute for Synthesis (NIMBioS) Bioengineering & Bioscience University of Tennessee Georgia Institute of Technology Arun Majumdar Joshua Kritzer Director of Energy Initiatives Assistant Professor of Chemistry Google.org Tufts University Fernando Martinez Joerg Lahann Director, BIO5 Institute Director, Biointerfaces Institute University of Arizona University of Michigan Marcia K. McNutt Cato Laurencin Editor in Chief, Science Wilda Van Dusen Distinguished American Association for the Professor of Orthopaedic Advancement of Science Surgery Professor of Chemical, Materials William Miller and Biomolecular Engineering Program Director CEO, Connecticut Institute for Directorate for Biological Sciences Clinical and Translational National Science Foundation Science Director, Institute for Regenerative Adrienne Minerick Engineering Associate Professor University of Connecticut Department of Chemical Engineering Michigan Technological University

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134 APPENDIX B Martha Mitchell Robert Nerem Associate Dean of Research Parker H. Petit Distinguished College of Engineering Chair for Engineering in New Mexico State University Medicine and Institute Professor Emeritus Simon Mochrie Former Director, Parker H. Petit Professor of Physics and Applied Institute for Bioengineering Physics and Bioscience Yale University Georgia Institute of Technology C.D. Mote, Jr. Corey O’Hern President Associate Professor National Academy of Engineering Departments of Mechanical Engineering & Materials Kelly Moynihan Science and Physics Graduate Student Yale University Department of Biological Engineering Monica Olvera de la Cruz Massachusetts Institute of Lawyer Taylor Professor of Technology Materials Science and Engineering Sarah Mueller Director, Materials Research Graduate Student Center University of North Carolina at Northwestern University Chapel Hill Maria Pellegrini Cherry Murray Executive Director of Programs Dean W. M. Keck Foundation School of Engineering and Applied Sciences Nicholas Peppas Harvard University Fletcher Stuckey Pratt Chair in Engineering Larry Nagahara Chair, Department of Biomedical Director, Office of Physical Engineering Sciences-Oncology Professor, Departments of National Cancer Institute Chemical Engineering, National Institutes of Health Biomedical Engineering and College of Pharmacy Eric Nawrocki University of Texas at Austin Bioinformatics Specialist Janelia Farm Research Campus James Petersson Howard Hughes Medical Institute Assistant Professor Department of Chemistry University of Pennsylvania

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APPENDIX B 135 Roderick Pettigrew David Roessner Director Senior Fellow National Institute of Biomedical Center for Science, Technology, Imaging and Bioengineering and Economic Development National Institutes of Health SRI International Rember Pieper Joann Roskoski Associate Professor, Deputy Assistant Director J. Craig Venter Institute Directorate for Biological Sciences National Science Foundation Manu Platt Assistant Professor Gerald Rubin Wallace H. Coulter Department of Executive Director Biomedical Engineering Janelia Farm Research Campus Georgia Institute of Technology Howard Hughes Medical Institute Manu Prakash Pamela J. Schofield Assistant Professor Manager, Corporate Research & Department of Bioengineering Development Stanford University The Procter & Gamble Company Lynne Regan Belinda Seto Professor Deputy Director Departments of Molecular National Institute of Biomedical Biophysics & Biochemistry Imaging and Bioengineering and Chemistry National Institutes of Health Yale University Armon Sharei Proctor Reid Graduate Student Program Director Department of Chemical National Academy of Engineering Engineering Massachusetts Institute of Gary Reiness Technology Associate Dean of the College of Arts and Sciences; Phillip Sharp Professor of Biology Institute Professor Lewis & Clark College Koch Institute for Integrative Cancer Research Sandra Robinson Massachusetts Institute of Graduate Student Technology Department of Biology University of Massachusetts Amherst

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136 APPENDIX B Lindsey Sharpe Daniel Solomon Graduate Student Dean, College of Sciences Cockrell School of Engineering North Carolina State University University of Texas at Austin Nelson Spruston Carla J. Shatz Scientific Program Director and Director, Bio-X Laboratory Head Professor of Biology and Janelia Farm Research Campus Neurobiology Howard Hughes Medical Institute Stanford University Stephanie Steichen Kamal Shukla Graduate Student Program Director, Molecular Cockrell School of Engineering Biophysics University of Texas at Austin Directorate for Biological Sciences National Science Foundation Andrea L. Stith Assistant Director for Carl Simon Interdisciplinary Education Founding Director, Center for the BioFrontiers Institute Study of Complex Systems University of Colorado Professor of Mathematics, Economics, and Public Policy Umesh Thakkar University of Michigan U.S. Government Accountability Office Dinah Singer Head, Molecular Regulation Katerina Thompson Section Director Director, Division of Cancer Undergraduate Research and Biology Internship Programs National Cancer Institute College of Computer, National Institutes of Health Mathematical, and Natural Sciences Susan Singer University of Maryland College Laurence McKinley Gould Park Professor Departments of Biology and Julie Thompson Klein Cognitive Science Professor of Humanities; and Carleton College English Department Faculty Director, Division of Fellow for Interdisciplinary Undergraduate Education Development National Science Foundation Wayne State University

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APPENDIX B 137 Matthew Tirrell Tina Winters Pritzker Director Associate Program Officer Institute for Molecular Board on Behavioral, Cognitive, Engineering and Sensory Sciences University of Chicago National Research Council Robert Tjian Jodi Yellin President Director, Group on Graduate Howard Hughes Medical Institute Research and Education Association of American Medical Hannah Valantine Colleges Senior Associate Dean for Diversity and Leadership Dorothy Zolandz Professor of Cardiovascular Deputy Director Medicine Division on Earth and Life Studies Stanford University School of National Research Council Medicine Board on Life Sciences Staff Amy Cheng Vollmer Professor of Biology Frances Sharples Swarthmore College Director Board on Life Sciences Geoffrey von Maltzen National Research Council New Venture Principal fsharples@nas.edu Flagship Ventures Katherine Bowman Evan Vosburgh Senior Program Officer Executive Director Board on Life Sciences Raymond and Beverly Sackler National Research Council Foundation kbowman@nas.edu Vivek Wadhwa Carl Anderson Vice President of Innovation and Program Associate Research Board on Life Sciences Singularity University National Research Council cganderson@nas.edu Bruce Walker Director Ayesha Ahmed Ragon Institute of MGH, MIT and Senior Program Assistant Harvard Board on Life Sciences National Research Council sahmed@nas.edu

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