Advances in Understanding Genetic Changes in Cancer: Impact on Diagnosis and Treatment Decisions in the 1990s

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Table 3-2 Cytogenetic-Immunophenotypic-Genomic Correlations in Malignant Lymphoid Diseases

Phenotype	Rearrangement	Involved Genes
Acute lymphoblastic leukemia
Pre-B	t(1;19)(q23;p13)	PBX	E2A
B(SIg+)	t(8;14)(q24;q32)	MYC	IGH
	t(2; 8)(p11–12;q24)	IGK	MYC
	t(8;22)(q24;q11)	MYC	IGL
	t(5;14)(q31;q32)	IL3	IGH
	dic(9;12)(p11;p12)
B or B-myeloid	t(9;22)(q34;q11)	ABL	BCR
	t(4;11)(q21;q23)		MLL
Other	hyperdiploidy
	(50–60 chromosomes)
	del(9p),t(9p)	IFNA/B
	del(12p),t(12p)
	t(8;17)(q24;q22)	MYC	BCL3^a
T	t(11;14)(p15;q11)	RBTN1	TCRD
	t(11;14)(p13;q11)	TCL2^b	TCRD
	t(8;14)(q24;q11)	MYC	TCRA
	inv(14)(q11q32.3)	IGH	TCRA
	inv(14)(q11q32.1)/	TCL1	TCRA
	t(14;14)(q11;q32)
	t(10;14)(q24;q11)	TCL3^a	TCRD
	t(1;14)(p32;q11)	TCL5	TCRD
	t(7;9)(q35;q32)	TCRB	SUP-T3^c
	t(7;9)(q35;q34)	TCRB	TAN1
	t(7;7)(p15;q11)	TCRG
	t(7;14)(p15;q11)	TCRG
	t(7;14)(q35;q11)
	t(7;19)(q35;p13)	TCRB	LYL1
Non-Hodgkin's lymphoma
B	t(8;14)(q24;q32)	MYC	IGH
	t(2;8)(p11–12;q24)	IGK	MYC
	t(8;22)(q24;q11)	MYC	IGL
	t(14;18)(q32;q21)	IGH	BCL2
	t(11;14)(q13;q32)	BCL1	IGH
T	see T-cell ALL
Chronic lymphocytic leukemia
B	t(11;14)(q13;q32)	BCL1	IGH
	t(14;19)(q32;q13)	IGH	BCL3^a
	t(2;14)(p13;q32)	IGH
	t(18;22)(q21;q11)	BCL2	IGL
	t(14q32)
	+12

Free Resources

Related Titles

Advances in Understanding Genetic Changes in Cancer: Impact on Diagnosis and Treatment Decisions in the 1990s (1992)
Institute of Medicine (IOM)

Free Resources

Related Titles

Advances in Understanding Genetic Changes in Cancer: Impact on Diagnosis and Treatment Decisions in the 1990s (1992) Institute of Medicine (IOM)

Advances in Understanding Genetic Changes in Cancer: Impact on Diagnosis and Treatment Decisions in the 1990s (1992)
Institute of Medicine (IOM)