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Advances in Understanding Genetic Changes in Cancer: Impact on Diagnosis and Treatment Decisions in the 1990s
ciple, is that the presence of the viral genomes in the cell acts as a cofactor in malignant transformation by stimulating the cell to divide, and that more rapid replication of cellular DNA predisposes the cell to mutation. Regardless of the mechanism of oncogenesis, the presence of viral genomes and virus-specific proteins produces changes in the genotype and phenotype of the host cell, and in some circumstances, these changes can serve as tumor-specific markers.