parameters measured in the animal model should mimic those measured in humans wherever possible.

Tissues obtained by biopsy and necropsy from patients, animals and their controls should be evaluated for pathologic changes. In addition, functional and morphological changes in cells and tissues should be evaluated using in vitro techniques.

ADDITIONAL NEEDS

Attempts should be made to develop a data base of chemicals, foods and drugs, and associated signs and symptoms, which have been reported to be associated with MCS. Evaluation of this data base should be explored to identify possible linkages between exposure and mechanisms.



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