National Academies Press: OpenBook
Suggested Citation:"Front Matter." National Research Council. 1992. Multiple Chemical Sensitivities: Addendum to Biologic Markers in Immunotoxicology. Washington, DC: The National Academies Press. doi: 10.17226/1988.
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Multiple Chemical Sensitivities

A Workshop

This workshop was conducted at the request of the Environmental Protection Agency. This volume contains the papers prepared and presented by individual workshop participants; the papers have not undergone peer review.

Board on Environmental Studies and Toxicology

Commission on Life Sciences

National Research Council

NATIONAL ACADEMY PRESS
Washington, D.C.
1992

Suggested Citation:"Front Matter." National Research Council. 1992. Multiple Chemical Sensitivities: Addendum to Biologic Markers in Immunotoxicology. Washington, DC: The National Academies Press. doi: 10.17226/1988.
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NATIONAL ACADEMY PRESS
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NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competencies and with regard for appropriate balance.

Procedures approved by the Report Review Committee of the National Research Council provide that reports be reviewed by a group other than the authors. This report has not received such a review.

The National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare. Upon the authority of the charter granted to it by the Congress in 1863, the Academy has a mandate that requires it to advise the federal government on scientific and technical matters. Dr. Frank Press is president of the National Academy of Sciences.

The National Academy of Engineering was established in 1964, under the charter of the National Academy of Sciences, as a parallel organization of outstanding engineers. It is autonomous in its administration and in the selection of its members, sharing with the National Academy of Sciences the responsibility for advising the federal government. The National Academy of Engineering also sponsors engineering programs aimed at meeting national needs, encourages education and research, and recognizes the superior achievements of engineers. Dr. Robert M. White is president of the National Academy of Engineering.

The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public. The Institute acts under the responsibility given to the National Academy of Sciences by its congressional charter to be an adviser to the federal government and, upon its own initiative, to identify issues of medical care, research, and education. Dr. Kenneth Shine is president of the Institute of Medicine.

The National Research Council was organized by the National Academy of Sciences in 1916 to associate the broad community of science and technology with the Academy’s purposes of furthering knowledge and advising the federal government. Functioning in accordance with general policies determined by the Academy, the Council has become the principal operating agency of both the National Academy of Sciences and the National Academy of Engineering in providing services to the government, the public, and the scientific and engineering communities. The Council is administered jointly by both Academies and the Institute of Medicine. Dr. Frank Press and Dr. Robert M. White are chairman and vice chairman, respectively, of the National Research Council.

The project was supported by the Environmental Protection Agency; the National Institute of Environmental Health Sciences; and the Comprehensive Environmental Response, Compensation, and Liability Act Trust Fund through cooperative agreement with the Agency for Toxic Substances and Disease Registry, U.S. Public Health Service, Department of Health and Human Services.

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International Standard Book No. 0-309-04736-6

Additional copies of this report are available from the
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Suggested Citation:"Front Matter." National Research Council. 1992. Multiple Chemical Sensitivities: Addendum to Biologic Markers in Immunotoxicology. Washington, DC: The National Academies Press. doi: 10.17226/1988.
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TABLE OF CONTENTS

 

 

Introduction,
Jonathan Samet and Devra Lee Davis

 

1

 

 

Research Protocols for Clinical Evaluation,

 

5

   

Working Group I

 

 

 

 

Exposures and Mechanisms,

 

9

   

Working Group II

 

 

 

 

Epidemiology,

 

11

   

Working Group III

 

 

 

 

Key Concepts: Chemical Sensitization,
Michael D. Lebowitz

 

13

 

 

Multiple Chemical Sensitivity-What is it?,
Roy L. DeHart

 

35

 

 

Case Definitions for Multiple Chemical Sensitivity,
Nicholas A. Ashford and Claudia S. Miller

 

41

 

 

Allergy and Multiple Chemical Sensitivities (MCS) Distinguished,
Claudia S. Miller and Nicholas A. Ashford

 

47

 

 

Design of Animal Models to Probe the Mechanisms of Hypersensitivity,
Meryl Karol

 

65

 

 

Antigen Specific and Antigen Non-Specific Immunization,
Robert Burrell

 

77

Suggested Citation:"Front Matter." National Research Council. 1992. Multiple Chemical Sensitivities: Addendum to Biologic Markers in Immunotoxicology. Washington, DC: The National Academies Press. doi: 10.17226/1988.
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Suggested Citation:"Front Matter." National Research Council. 1992. Multiple Chemical Sensitivities: Addendum to Biologic Markers in Immunotoxicology. Washington, DC: The National Academies Press. doi: 10.17226/1988.
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Suggested Citation:"Front Matter." National Research Council. 1992. Multiple Chemical Sensitivities: Addendum to Biologic Markers in Immunotoxicology. Washington, DC: The National Academies Press. doi: 10.17226/1988.
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Suggested Citation:"Front Matter." National Research Council. 1992. Multiple Chemical Sensitivities: Addendum to Biologic Markers in Immunotoxicology. Washington, DC: The National Academies Press. doi: 10.17226/1988.
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Suggested Citation:"Front Matter." National Research Council. 1992. Multiple Chemical Sensitivities: Addendum to Biologic Markers in Immunotoxicology. Washington, DC: The National Academies Press. doi: 10.17226/1988.
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Multiple Chemical Sensitivities: Addendum to Biologic Markers in Immunotoxicology Get This Book
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Use of the term "multiple chemical sensitivity" (MCS) as a diagnostic label has generated increasing controversy during the past few decades as a phenomenon related to exposure to chemical agents sustained both in indoor and outdoor environments.

This volume, prepared in conjunction with Biologic Markers in Immunotoxicology, contains the authored papers of a workshop held to develop an agenda to study the phenomenon of multiple chemical sensitivity. Authored by clinicians, immunologists, toxicologists, epidemiologists, psychiatrists, psychologists, and others involved in research or clinical activities relevant to the problem, the papers contain case evaluations and criteria for diagnosis, mechanisms potentially underlying MCS, and epidemiologic approaches to investigation.

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