TABLE 3-4 Characteristics of Syndromes Related to Inhalation of TMA

Characteristic

Rhinitis and Immediate-Type Asthma

LRSS

Pulmonary Disease-Anemia

Irritant Syndromes

Latent period (duration of exposure prior to onset of symptoms)

Weeks to months of work exposure

Weeks to months of work exposure

Weeks to months of work exposure

Occurs on first high-work dose exposure

Onset of symptoms

after work exposure

Immediate (minutes)

4–12 hours

Progressive with further work exposure

Variable, depending on exposure

Degree (type) of exposure

TMA dust (mild) or fumes

TMA dust (moderate) or fumes

TMA fumes (heavy)

Fumes or dust (great)

Skin tests (TM-HSA)

Positive immediate-type

Negative

Not done

Negative

Total antibody to TM-HSA

Present

High

Very high

Variable

IgE to TM-HSA

Present

Absent

Absent

Absent

NOTE: TMA, trimellitic anhydride; LRSS, late respiratory systemic syndrome; TM-HSA, trimellitic anhydride-human serum albumin.

SOURCE: Zeiss et al., 1982.



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