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FIGURE I-1 Relative carcinogenic potency of three nitrogen derivative antineoplastic agents. SOURCE: Kaldor et al., 1988

melphalan. Kaldor and colleagues (1988) have calculated a leukemia potency index (10-year incidence per gram total dose) for each of these drugs and compared it with the corresponding rodent TD50's. Figure I-1 is a graphic representation of data from Kaldor and colleagues (1988) of the reciprocal of the TD50's for various antineoplastic drugs plotted against the relative human leukemogenic potency. No data exist that would allow a direct estimate to be made of the human leukemia potency index for HN2-HCl, but its TD50 in male rats (0.23 mg/kg per day) would suggest that its relative leukemogenic potency would be comparable to or exceed that of melphalan. This comparability is also suggested by comparing the pulmonary tumorigenic potency of HN2 and the other compounds in the strain A mice bioassay data of Shimkin



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