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TABLE 6-3 Tumors from Subcutaneous Injection of Sulfur and Nitrogen Mustard into C3H Mice and Sulfur Mustard into C3Hf Mice

No. of Injections

Sex

 

No.

Average Months Survival

Tumors at Site of Injection

Tumors at Other Sites

0.05 cc 0.05% soln. of sulfur mustard in olive oil into C3H mice

6

M

 

8

14.3

1 Sarcoma

2 Pulmonary tumors

6

F

 

8

8.9

0

8 Mammary tumors

 

 

 

 

 

 

1 Hepatoma

6

M

 

24

13.1

1 Rhabdomyosarcoma

7 Hepatomas

0.25 mg HN2 in 0.25 cc water into C3H mice

8

M

(8)

7

10.6

1 Papilloma

3 Pulmonary tumors

 

 

 

 

 

1 Squamous cell carcinoma

 

8

F

 

8

8.6

1 Papilloma

2 Pulmonary tumors

 

 

 

 

 

 

7 Mammary tumors

6

M

(24)

21

17

3 Sarcomas

8 Pulmonary tumors

 

 

 

 

 

2 Neurogenic sarcomas

9 Hepatoma

 

 

 

 

 

1 Hemangioendothelioma

2 Liver hemangioendothelioma

C3H control mice  

 

M

 

8

14

 

1 Pulmonary tumor

 

 

 

 

 

 

2 Hepatomas

 

 

 

8

7.4

 

7 Mammary tumors

 

M

(8)

6

14.3

 

1 Pulmonary tumor

 

F

 

8

11.1

 

2 Pulmonary tumors

 

 

 

 

 

 

7 Mammary tumors

 

M

(24)

21

15.5

 

5 Pulmonary tumors

 

 

 

 

 

 

9 Hepatomas

0.05 cc 0.05% soln. of sulfur mustard in olive oil into C3Hf mice

6

F

(10)

9

15.4

2 Sarcomas

1 Pulmonary tumor

 

 

 

 

 

1 Mammary tumor

1 Mammary tumor

6

M

(40)

38

16.8

2 Sarcomas

5 Pulmonary tumors

 

 

 

 

 

 

22 Hepatomas

0.25 mg HN2 in 0.25 cc distilled water into C3Hf mice

6

M

(41)

37

16.1

2 Sarcomas

21 Pulmonary tumors

 

 

 

 

 

1 Papilloma

17 Hepatomas

 

 

 

 

 

 

1 Reticulum cell sarcoma

 

 

 

 

 

 

1 Lymphocytic leukemia

 

 

 

 

 

 

1 Liver hemangioendothelioma

C3Hf control mice  

 

M

(40)

39

16.3

 

6 Pulmonary tumors

 

 

 

 

 

 

18 Hepatomas

 

 

 

 

 

 

2 Lymphoytic leukemias

 

 

 

 

 

 

1 Skin squamous carcinoma

NOTE: Table does not include data from one high-dose group, due to the high mortality reported. Numbers in parentheses reflect number of animals initially injected.

SOURCE: Heston, 1953a.



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