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Issues in Risk Assessment ments on this article. An earlier version of this paper was presented on September 6, 1990 in Washington, D.C. at the Workshop on Maximum Tolerated Dose: Implications for Risk Assessment sponsored by the U.S. National Academy of Sciences Committee on Risk Assessment Methodology, and discussed by Drs. Edmund Crouch and Lauren Zeise. A draft of this paper was also presented at the International Environmetrics Conference held in Como, Italy, from September 27-October 2, 1990. 9. References Allen, B., Crump, K. & Shipp, A. (1988a). Carcinogenic potencies of chemicals in animals and humans. Risk Analysis 8, 531-544. Allen, B., Crump, K. & Shipp, A. (1988b). Is it possible to predict the carcinogenic potency of a chemical in humans using animal data? (with discussion). In Banbury Report 31: Carcinogen Risk Assessment: New Directions in the Qualitative and Quantitative Aspects. Cold Spring Harbor Laboratory, Cold Spring Harbor, pp. 197-209. Ames, B.N., Magaw, R. & Gold, L.S. (1987). Ranking possible carcinogenic hazards. Science 236, 271-280. Ames, B.N. & Gold, L.S. (1990). Too many rodent carcinogens: mitogenesis increases mutagenesis. Science 249, 970-971. Andersen, M.A., Clewell, H.J., Gargas, M.L., Smith, F.A. & Reitz, R.H. (1987). Physiologically based pharmacokinetics and the risk assessment process for vinyl chloride. Toxicology and Applied Pharmacology 87, 185-205. Apostolou, A. (1990). Relevance of maximum tolerated dose to human carcinogenic risk. Regulatory Toxicology and Pharmacology 11, 68-80. Armitage, P. (1985). Multistage models of carcinogenesis. Environmental Health Perspectives 63, 195-201. Ashby, J. & Tenant, R.W. (1988). Chemical structure, Salmonella mutagenicity and extent of carcinogenicity as indicators of genotoxic carcinogenesis among 222 chemicals tested in rodents by the U.S. NCI/NTP. Mutation Research 204, 17-115. Bailar, A.J. & Portier, C.J. (1992). An index of tumorigenic potency. Biometrics. In press.
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