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Appendix B
Workshop Program

Thursday, November 8, 1990

8:30

Welcome: Donald Mattison, University of Pittsburgh Committee Vice-Chairman

8:35

Introduction and Objectives: Richard Griesemer, NIEHS Workshop Chairman

8:45

Biological Factors in Two-Stage Models

 

Presenter: Alfred Knudson, Fox Chase Cancer Center

9:30

Discussant: Robert Maronpot, NIEHS

9:50

Questions and Comments

10:10

Break

10:30

Two-Stage Clonal Expansion Model of Carcinogenesis

 

Presenter: Suresh Moolgavkar, Fred Hutchinson Cancer Research Center

11:15

Discussants: James Wilson, Monsanto; Robert Sielken, Sielken, Inc.; Todd Thorslund, Clement Associates, Inc.

12:00

Questions and Comments



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OCR for page 233
APPENDIX B 233 original typesetting files. Page breaks are true to the original; line lengths, word breaks, heading styles, and other typesetting-specific formatting, however, cannot be About this PDF file: This new digital representation of the original work has been recomposed from XML files created from the original paper book, not from the retained, and some typographic errors may have been accidentally inserted. Please use the print version of this publication as the authoritative version for attribution. Appendix B Workshop Program Thursday, November 8, 1990 8:30 Welcome: Donald Mattison, University of Pittsburgh Committee Vice- Chairman 8:35 Introduction and Objectives: Richard Griesemer, NIEHS Workshop Chairman 8:45 Biological Factors in Two-Stage Models Presenter: Alfred Knudson, Fox Chase Cancer Center 9:30 Discussant: Robert Maronpot, NIEHS 9:50 Questions and Comments 10:10 Break 10:30 Two-Stage Clonal Expansion Model of Carcinogenesis Presenter: Suresh Moolgavkar, Fred Hutchinson Cancer Research Center 11:15 Discussants: James Wilson, Monsanto; Robert Sielken, Sielken, Inc.; Todd Thorslund, Clement Associates, Inc. 12:00 Questions and Comments

OCR for page 233
APPENDIX B 234 original typesetting files. Page breaks are true to the original; line lengths, word breaks, heading styles, and other typesetting-specific formatting, however, cannot be About this PDF file: This new digital representation of the original work has been recomposed from XML files created from the original paper book, not from the retained, and some typographic errors may have been accidentally inserted. Please use the print version of this publication as the authoritative version for attribution. 12:15 Lunch 1:15 Application of the Two-Stage Model to Animal Data Presenter: Samuel Cohen, University of Nebraska Medical Center 2:00 Discussants: William Farland, EPA; Carl Barrett, NIEHS 2:30 Questions and Comments 2:45 General Discussion Leader: Richard Griesemer, NIEHS Issues: • The scientific basis for two-stage models of carcinogenesis. • Can two-stage models of carcinogenesis adequately represent biological processes that may involve a variety of mechanisms? • The implications for the design of rodent bioassays. • The implications for health risk assessment. 3:30 Adjourn