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Issues in Risk Assessment (1993)
Commission on Life Sciences (CLS)

Page
351
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Issues in Risk Assessment

Appendix J
Workshop Program

February 26 - March 1, 1991

Airlie Foundation

Warrenton, VA

TUESDAY, FEBRUARY 26, 1991

4:00

WELCOME Bernard Goldstein, Committee Chairman, Robert Wood Johnson Medical School

4:15

DISCUSSION OF PURPOSE Lawrence Barnthouse, Workshop Chairman, Oak Ridge National Laboratory

KEYNOTE SPEECHES

4:30

Broad Policy View, Terry Yosie, American Petroleum Institute

5:00

Relationship of Workshop to NRC's 1983 Risk Assessment Study Warner North, Decision Focus, Inc.
Page
351
Front Matter (R1-R18)
Executive Summary (1-12)
Use of the Maximum Tolerated Dose in Animal Bioassays for Carcinogenicity (13-14)
1 Introduction (15-20)
2 Correlations Between Carcinogenic Potency and Other Measures of Toxicity (21-42)
3 Advantages and Disadvantages of Bioassys That Use the MTD (43-52)
4 Options Considered (53-60)
5 Conclusions and Recommendations (61-66)
References (67-78)
Appendix A: Workshop Summary - Maximum Tolerated Dose: Implications for Risk Assessment (79-90)
Appendix B: Workshop Organizing Subcommittee (91-92)
Appendix C: Workshop Federal Liaison Group (93-94)
Appendix D: Workshop Programs (95-96)
Appendix E: Workshop Attendees (97-110)
Appendix F: Correlation Between Carcinogenic Potency and the Maximum Tolerated Dose: Implications for Risk Assessment (111-172)
Appendix G: Informal Search for Supercarcinogens (173-184)
The Two-Stage Model of Carcinogenesis (185-186)
Issues in Risk Assessment (187-216)
References (217-222)
Appendix A: Workshop Summary - Two-Stage Modelsof Carcinogenesis (223-232)
Appendix B: Workshop Program (233-234)
Appendix C: Workshop Federal Liaison Group (235-236)
Appendix D: Workshop Attendees (237-238)
Appendix E: Workshop Organizing Task Group (239-240)
A Paradigm for Ecological Risk Assessment (241-242)
1 Introduction (243-246)
2 Scope of Ecological Risk Assessment (247-248)
3 Revision of 1983 Framework to Incorporate Ecological Risk Assessment (249-258)
4 Key Scientific Problems Limiting Application of Ecological Risk Assessment (259-264)
5 Conclusions (265-266)
6 Recommendations (267-268)
References (269-272)
Appendix A: Workshop Participants (273-278)
Appendix B: Workshop Organizing Subcommittee and Federal Liaison Group (279-280)
Appendix C: Workshop Introduction (281-282)
Appendix D: Opening Plenary Presentations (283-292)
Appendix E: Case Studies and Commentaries (293-308)
Appendix F: Breakout Sessions (309-336)
Appendix G: Contemplations on Ecological Risk Assessment (337-342)
Appendix H: Workshop Summary (343-346)
Appendix I: References for Appendixes (347-350)
Appendix J: Workshop Program (351-356)

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OCR for page 351
Issues in Risk Assessment Appendix J Workshop Program February 26 - March 1, 1991 Airlie Foundation Warrenton, VA TUESDAY, FEBRUARY 26, 1991 4:00 WELCOME Bernard Goldstein, Committee Chairman, Robert Wood Johnson Medical School 4:15 DISCUSSION OF PURPOSE Lawrence Barnthouse, Workshop Chairman, Oak Ridge National Laboratory KEYNOTE SPEECHES 4:30 Broad Policy View, Terry Yosie, American Petroleum Institute 5:00 Relationship of Workshop to NRC's 1983 Risk Assessment Study Warner North, Decision Focus, Inc.

OCR for page 352
Issues in Risk Assessment 5:30 U.S. EPA Activities in Ecological Risk Assessment Michael Slimak, ORD, U.S. EPA WEDNESDAY, FEBRUARY 27, 1991 CASE STUDIES CHEMICAL STRESSORS 8:30 Tributyl tin Robert Huggett, Virginia Institute of Marine Science 8:55 Discussants: Lawrence Barnthouse, Oak Ridge National Laboratory 9:05 Discussants: Peter Seligman, Naval Ocean Systems Center 9:15 General Discussion 9:30 Agrochemicals Ronald Kendall, Clemson University 9:55 Discussants: Bill Williams, Ecological Planning and Toxicology, Inc. 10:05 Discussants: James Gagne, American Cyanamid Company 10:15 General Discussion 10:30 Break 11:00 PCBs and TCDD Dominic DiToro, Manhattan College 11:25 Discussants: Dennis Paustenbach, McLaren/Hart 11:35 Discussants: Larry Burns, U.S. EPA, Athens, GA 11:45 General Discussion noon Lunch OTHER STRESSORS 1:30 Habitat loss (spotted owl) David Anderson, U.S. Fish & Wildlife Service

OCR for page 353
Issues in Risk Assessment 1:55 Discussants: Orie Loucks, Miami University, OH 2:05 Discussants: Mary Kentula, U.S. EPA, Corvailis, OR 2:15 General Discussion 2:30 Introduction of species Ray Carruthers, USDA, Cornell University 2:55 Discussants: David Policansky, National Research Council 3:05 Discussants: James Carlton, Williams College 3:15 General Discussion 3:30 Break 4:00 Harvesting (George's Bank Fisheries) Andrew Rosenberg, National Marine Fisheries Service 4:25 Discussants: J. Larry Ludke, U.S. Fish and Wildlife Service 4:35 Discussants: Randall Peterman, Simon Fraser University 4:45 General Discussion 5:00 Adjourn THURSDAY, FEBRUARY 28, 1991 BREAKOUT SESSIONS 7:30 Breakfast 8:30 RELEVANCE OF NRC 1983 RED BOOK PARADIGM TO ECOLOGICAL RISK ASSESSMENT   Hazard identification Alan Maki, Exxon Corporation Dorothy Patton, Risk Assessment Forum, U.S. EPA   Dose-response assessment John Bailar, McGill University School of Medicine Judy Meyer, University of Georgia

OCR for page 354
Issues in Risk Assessment   Exposure assessment Brian Leaderer, Yale University School of Medicine Don Porcella, Electric Power Research Institute   Risk characterization William Farland, OHEA, U.S. EPA Glenn Suter, Oak Ridge National Laboratory 10:00 Break 10:30 Reconvene 12:30 Lunch 1:30 ANALYTICAL ISSUES IN ECOLOGICAL RISK ASSESSMENT   Modeling Robert Costanza, University of Maryland David Mauriello, U.S. EPA   Uncertainty Richard Kimerle, Monsanto Company Eric Smith, Virginia Polytechnic Institute and State University   Valuation William Desvousges, Research Triangle Institute F. Reed Johnson, U.S. Naval Academy   Relationship of risk assessment to regulatory process Warner North, Decision Focus, Inc. William Cooper, Michigan State University 3:30 Break 4:00 Reconvene 6:00 Adjourn

OCR for page 355
Issues in Risk Assessment 6:30 Dinner   Speaker Erich W. Bretthauer, Assistant Administrator for Research and Development, U.S. EPA FRIDAY, MARCH 1, 1991 CONCLUDING PLENARY SESSION 7:30 Breakfast RELEVANCE OF NRC 1983 RED BOOK PARADIGM TO ECOLOGICAL RISK ASSESSMENT 8:00 CONTEMPLATIONS ON ECOLOGICAL RISK ASSESSMENT Thomas Lovejoy, Smithsonian Institution 8:30 Hazard identification, Maki and Patton 8:45 Dose-response assessment, Bailar and Meyer 9:00 Exposure assessment, Leaderer and Porcella 9:15 Risk characterization, Farland and Suter 9:30 Discussion, North 10:00 Break ANALYTICAL ISSUES IN ECOLOGICAL RISK ASSESSMENT 10:15 Modeling, Costanza and Mauriello 10:30 Uncertainty, Kimerle and Smith 10:45 Valuation, Desvousges and Johnson

OCR for page 356
Issues in Risk Assessment 11:00 Relationship of risk assessment to regulatory process, North and Cooper 11:15 Discussion, Barnthouse 11:45 Conclusion, Barnthouse noon Lunch/Adjourn

Representative terms from entire chapter:

decision focus