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PAPERBACK list:$49.00 Web:$44.10 add to cart PDF BOOK your price: $37.50 add to cart Rights & Permissions Free Resources PDF EXECUTIVE SUMMARY Display this book on your site! Related Titles Health Risks from Dioxin and Related Compounds: Evaluation of the EPA Reassessment Toxicity Testing for Assessment of Environmental Agents: Interim Report Other Related Titles Issues in Risk Assessment (1993) Commission on Life Sciences (CLS) Web Search Builder Use this book's key terms to search within this book, across our collection, or across the Web. Skim This Chapter Skim this chapter and use this chapter's key terms to search within this book. Reference Finder Paste in your own text to find books that relate to your topic. Page 95   E-mail  Facebook  Digg  Stumble  Twitter More The following HTML text is provided to enhance online readability. Many aspects of typography translate only awkwardly to HTML. Please use the page image as the authoritative form to ensure accuracy. Appendix D Workshop Program Thursday, September 6, 1990 Lecture Room, National Academy of Sciences 2101 Constitution Ave., NW Washington, DC 9:00 Introduction and Objectives: Kenny Crump, Clement Associates; Chairman 9:15 Definition and Application of MTD   Presenter: Eugene McConnell, Raleigh, NC 9:45 Discussants: John Emmerson, Eli Lilly and Co.; Ian Munro, University of Guelph 10:05 Questions and Comments 10:15 Break 10:30 Correlations between the MTD and Measures of Carcinogenic Potency: Implications for Risk Assessment   Presenter: Daniel Krewski, Health and Welfare Canada 11:15 Discussants: Kenny Crump, Clement Associates; Lauren Zeise, California Department of Health Services; Thomas Starr, Environ Corp.; Page 95 Front Matter (R1-R18) Executive Summary (1-12) Use of the Maximum Tolerated Dose in Animal Bioassays for Carcinogenicity (13-14) 1 Introduction (15-20) 2 Correlations Between Carcinogenic Potency and Other Measures of Toxicity (21-42) 3 Advantages and Disadvantages of Bioassys That Use the MTD (43-52) 4 Options Considered (53-60) 5 Conclusions and Recommendations (61-66) References (67-78) Appendix A: Workshop Summary - Maximum Tolerated Dose: Implications for Risk Assessment (79-90) Appendix B: Workshop Organizing Subcommittee (91-92) Appendix C: Workshop Federal Liaison Group (93-94) Appendix D: Workshop Programs (95-96) Appendix E: Workshop Attendees (97-110) Appendix F: Correlation Between Carcinogenic Potency and the Maximum Tolerated Dose: Implications for Risk Assessment (111-172) Appendix G: Informal Search for Supercarcinogens (173-184) The Two-Stage Model of Carcinogenesis (185-186) Issues in Risk Assessment (187-216) References (217-222) Appendix A: Workshop Summary - Two-Stage Modelsof Carcinogenesis (223-232) Appendix B: Workshop Program (233-234) Appendix C: Workshop Federal Liaison Group (235-236) Appendix D: Workshop Attendees (237-238) Appendix E: Workshop Organizing Task Group (239-240) A Paradigm for Ecological Risk Assessment (241-242) 1 Introduction (243-246) 2 Scope of Ecological Risk Assessment (247-248) 3 Revision of 1983 Framework to Incorporate Ecological Risk Assessment (249-258) 4 Key Scientific Problems Limiting Application of Ecological Risk Assessment (259-264) 5 Conclusions (265-266) 6 Recommendations (267-268) References (269-272) Appendix A: Workshop Participants (273-278) Appendix B: Workshop Organizing Subcommittee and Federal Liaison Group (279-280) Appendix C: Workshop Introduction (281-282) Appendix D: Opening Plenary Presentations (283-292) Appendix E: Case Studies and Commentaries (293-308) Appendix F: Breakout Sessions (309-336) Appendix G: Contemplations on Ecological Risk Assessment (337-342) Appendix H: Workshop Summary (343-346) Appendix I: References for Appendixes (347-350) Appendix J: Workshop Program (351-356)

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Issues in Risk Assessment Appendix D Workshop Program Thursday, September 6, 1990 Lecture Room, National Academy of Sciences 2101 Constitution Ave., NW Washington, DC 9:00 Introduction and Objectives: Kenny Crump, Clement Associates; Chairman 9:15 Definition and Application of MTD   Presenter: Eugene McConnell, Raleigh, NC 9:45 Discussants: John Emmerson, Eli Lilly and Co.; Ian Munro, University of Guelph 10:05 Questions and Comments 10:15 Break 10:30 Correlations between the MTD and Measures of Carcinogenic Potency: Implications for Risk Assessment   Presenter: Daniel Krewski, Health and Welfare Canada 11:15 Discussants: Kenny Crump, Clement Associates; Lauren Zeise, California Department of Health Services; Thomas Starr, Environ Corp.;

OCR for page 96
Issues in Risk Assessment   Edmund Crouch, Cambridge Environmental, Inc. 12:00 Questions and Comments 12:30 Lunch 2:00 What are Bioassays Conducted at the MTD Telling Us?   Presenter: Bruce Ames, University of California, Berkeley 2:45 Discussants: Michael Gallo, University of Medicine and Dentistry of New Jersey; David Gaylor, National Center for Toxicological Research 3:15 Questions and Comments 3:30 Break 3:45 General Discussion   Leader: Kenny Crump, Clement Associates   Issues:   • The basis of the observed correlation between the MTD and measures of carcinogenic potency • The possible influence on biological processes of dosing at this level • The implications for the design of rodent bioassays • The implications for carcinogenic risk assessment 5:00 Adjourn

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clement associates