An exercise-induced erythrocyte uptake of magnesium, has also been argued based on the idea that it is needed for 2, 3-diphosphoglycerate synthesis (Lukaski et al., 1983).
However, we have done a study (Lowney et al., 1990) where we looked at the influence of magnesium deficiency on erythrocyte 2, 3-diphosphoglycerate production, and it had no influence on 2, 3-diphosphoglycerate levels.
PARTICIPANT: How about the endurance study with magnesium deficiency in the animal. Why didn't that continue to go on down as you have a more severe deficiency. Here is a plateau in fact.
DR. KEEN: Yes, it is a plateau. Unfortunately, you can't get animals much more deficient and get meaningful data. We were curious if we could get a dose response using animals fed diets containing less than 50 µg of magnesium per gram, however once pronounced signs of magnesium deficiency occurred, it was difficult to get the males to run.
DR. NESHEIM: Thank you, Carl. That was very interesting and challenging and indeed reports some of the work that needs to be done.