Bartusiak, Marcia F., Burke, Barbara, Chaikin, Andrew, Greenwood, Addison, Heppenheimer, T.A., Hoffman, Michelle, Holzman, David, Maggio, Elizabeth J., Moffat, Anne Simon. "10 Fold, Spindle, and Regulate: How Proteins Work." A Positron Named Priscilla: Scientific Discovery at the Frontier. Washington, DC: The National Academies Press, 1994.
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A Positron Named Priscilla: Scientific Discovery at the Frontier
No doubt the quest for the Holy Grail will continue for years, if not decades. Researchers are only beginning to design novel proteins while sitting at the keyboard. The amino acid chain remains a Rosetta stone with the wealth of information on how proteins fold largely undeciphered. Nonetheless, the empirical data that researchers have collected are beginning to yield patterns that are providing valuable clues as well as insights into the mechanisms of gene regulation, which is one of the most fundamental processes in biology. The coiled coil, says Alber, "although simple, has been especially rich. On the one hand, we are finding out how protein-protein interactions control gene expression. On the other hand, we've described a simple structural motif in enough detail that we now think we know how to design this motif. This is a small step in the direction of being able to design proteins."
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