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Suggested Citation:"REFERENCES." National Research Council. 1995. Calculating the Secrets of Life: Contributions of the Mathematical Sciences to Molecular Biology. Washington, DC: The National Academies Press. doi: 10.17226/2121.
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THE SECRETS OF LIFE: A MATHEMATICIAN'S INTRODUCTION TO MOLECULAR BIOLOGY 24 lives. If this book makes progress toward these three goals, it shall have been well worth the effort. REFERENCES Alberts, B., D. Bray, J. Lewis, M. Raff, K. Roberts, and J.D. Watson, 1989, Molecular Biology of the Cell, 2nd ed., New York: Garland. Avery, O.T., C.M. McLeod, and M. McCarty, 1944, "Studies on the chemical nature of the substance inducing transformation of pneumococcal types," J. Exp. Med. 79, 137-158. Lewin, B., 1990, Genes IV, Oxford: Oxford University Press. National Research Council, 1988, Mapping and Sequencing the Human Genome, Washington, D.C.: National Academy Press. National Research Council, 1992, DNA Technology in Forensic Science,Washington, D.C.: National Academy Press. Richardson, J. S., and D. C. Richardson, 1989, "Principles and patterns of protein conformation," pp. 1-98 in Prediction of Protein Structure and the Principles of Protein Conformation, Gerald D. Fasman (ed.), New York: Plenum Publishing Corporation. Riordan, J.R., J.M. Rommens, B. Kreme, N. Alon, R. Rozmahel, Z. Grzelczak, J. Zielenski, S. Lok, N. Plavsic, J-L. Chou, M.L. Drumm, M.C. Innuzzi, F.S. Collins, and L-C. Tsui, 1989, "Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA," Science 245 (September 8), 10661073. Sali, A., E. Shakhnovich, and M. Karplus, 1994. "How does a protein fold?" Nature 369 (19 May), 248-251. Streyer, Lubert, 1988, Biochemistry, San Francisco, Calif.: W.H. Freeman. U.S. Department of Energy, Human Genome Program, 1992, Primer on Molecular Genetics , Office of Energy Research, Office of Health and Environmental Research, Washington, D.C.: U.S. Government Printing Office. Watson, J.D., N. Hopkins, J. Roberts, J.A. Steitz, and A. Weiner, 1987, Molecular Biology of the Gene, Menlo Park, Calif.: Benjamin- Cummings. Watson, J.D., J. Tooze, and D.T. Kurtz, 1994. Recombinant DNA: A Short Course, 2nd ed., New York: W.H. Freeman and Co.

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As researchers have pursued biology's secrets to the molecular level, mathematical and computer sciences have played an increasingly important role—in genome mapping, population genetics, and even the controversial search for "Eve," hypothetical mother of the human race.

In this first-ever survey of the partnership between the two fields, leading experts look at how mathematical research and methods have made possible important discoveries in biology.

The volume explores how differential geometry, topology, and differential mechanics have allowed researchers to "wind" and "unwind" DNA's double helix to understand the phenomenon of supercoiling. It explains how mathematical tools are revealing the workings of enzymes and proteins. And it describes how mathematicians are detecting echoes from the origin of life by applying stochastic and statistical theory to the study of DNA sequences.

This informative and motivational book will be of interest to researchers, research administrators, and educators and students in mathematics, computer sciences, and biology.

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