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Page 278
Chirality, 213-215
Chromosomal walking, 17, 18, 42, 43
Clones and cloning, 13, 14, 26, 42-43, 209
Closed circular DNA, 153-154, 155, 156, 157, 181, 204
Coalescent, 117, 119-121
combinatorial structures, 119, 136-148
Ewens sampling formula, 119, 122-124, 136-139
K-allele model, 130-132
likelihood methods, 146-148
tree construction and movement, 124-127
see also, Finitely-many-sites model; Infinitely-many-sites model
Codons, 12, 115, 239
Colon cancer, 34, 37-42
Combinatorics, 119, 136-148, 185
Computing time and memory capacity
algorithmic efficiencies, 35-36, 84-86, 87
approximate pattern matching, 79, 87
dynamic programming algorithms, 62-63, 64, 68, 83, 84
gap cost functions, 72
heuristic algorithms, 83-84
K-best paths, 77
multiple alignments, 75
parallel processing, 79-81, 84
sublinear similarity searches, 84-85
Consecutive ones property, 50
Consensus scores, 76
Contigs, 47-50
Crick and Watson model, 153, 204-205
Crossovers, 27-29
Cruciforms, 154
Crystallography, 202, 203, 240
Cystic fibrosis (CF), 16-18, 20-21, 26
Cytosine (C), 8, 9, 99
D
Databases of DNA sequences, 13, 17, 56, 81, 87
similarity searches in, 78-79, 82-86, 87, 91-92, 94
see also FASTA, BLASTA
Dayhoff matrix, 66, 67, 83
Diagnostics, see Genetic diagnostics
Difference measures, 72-73
Diffusion processes, 37-42, 148
Dimers, 212
DNA (deoxyribonucleic acid), 8-9, 92
primers, 13, 15, 16
protein binding, 166-167, 168, 170-171, 181
transcription, 9-12, 154, 179, 196-198, 204-205
see also DNA polymorphisms and mutations; Protein folding; Sequence similarity and comparison; Sequencing methods and