Page 278

Chirality, 213-215

Chromosomal walking, 17, 18, 42, 43

Clones and cloning, 13, 14, 26, 42-43, 209

Closed circular DNA, 153-154, 155, 156, 157, 181, 204

Coalescent, 117, 119-121

combinatorial structures, 119, 136-148

Ewens sampling formula, 119, 122-124, 136-139

K-allele model, 130-132

likelihood methods, 146-148

tree construction and movement, 124-127

see also, Finitely-many-sites model; Infinitely-many-sites model

Codons, 12, 115, 239

Colon cancer, 34, 37-42

Combinatorics, 119, 136-148, 185

Computing time and memory capacity

algorithmic efficiencies, 35-36, 84-86, 87

approximate pattern matching, 79, 87

dynamic programming algorithms, 62-63, 64, 68, 83, 84

gap cost functions, 72

heuristic algorithms, 83-84

K-best paths, 77

multiple alignments, 75

parallel processing, 79-81, 84

sublinear similarity searches, 84-85

Consecutive ones property, 50

Consensus scores, 76

Contigs, 47-50

Crick and Watson model, 153, 204-205

Crossovers, 27-29

Cruciforms, 154

Crystallography, 202, 203, 240

Cystic fibrosis (CF), 16-18, 20-21, 26

Cytosine (C), 8, 9, 99

D

Databases of DNA sequences, 13, 17, 56, 81, 87

similarity searches in, 78-79, 82-86, 87, 91-92, 94

see also FASTA, BLASTA

Dayhoff matrix, 66, 67, 83

Diagnostics, see Genetic diagnostics

Difference measures, 72-73

Diffusion processes, 37-42, 148

Dimers, 212

DNA (deoxyribonucleic acid), 8-9, 92

primers, 13, 15, 16

protein binding, 166-167, 168, 170-171, 181

transcription, 9-12, 154, 179, 196-198, 204-205

see also DNA polymorphisms and mutations; Protein folding; Sequence similarity and comparison; Sequencing methods and



The National Academies | 500 Fifth St. N.W. | Washington, D.C. 20001
Copyright © National Academy of Sciences. All rights reserved.
Terms of Use and Privacy Statement