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Science and Judgment in Risk Assessment (1994)
Board on Environmental Studies and Toxicology (BEST)

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. "Appendix G: Improvement in Human Health Risk Assessment Utilizing Site- and Chemical-Specific Information: A Case Study." Science and Judgment in Risk Assessment. Washington, DC: The National Academies Press, 1994.

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Page 502

5. Integrated Risk Information System (IRIS), 1992. U.S. EPA Information Network On-Line Database. Data retrieved January, 1992.

6. Price, P.S., Sample, J., Streiter, R., 1991. PSEM. A model of Long-Term Exposures to Emissions from Point Sources. Presented at the 84th annual meeting of the Air and Waste Management Association, Vancouver, British Columbia, June 16-21, 1991. 91-172.3.

7. Radian Corporation, 1990. Site-Specific Evaluation of Potential Cancer Risk Associated with 1,3-Butadiene Emissions from the Texaco, Port Neches Facility. Prepared for Texaco Chemical Company, May 14, 1990.

8. Radian Corporation, 1992a. Site-Specific Evaluation of Potential Cancer Risk Associated with 1,3-Butadiene Emissions from the Texaco, Port Neches Facility. Prepared for Texaco Chemical Company, April 16, 1992.

9. Radian Corporation, 1992b. Technical Memorandum from Randy Parmley, Radian Corporation to Jim Kmiecik, Texaco Chemical Company on "Summary of ISCST and ISCLT Model Comparison," dated 31 January 1992.

10. Radian Corporation 1992c. Site-Specific Evaluation of Potential Cancer Risk Associated with 1,3-Butadiene Emissions from the Texaco, Port Neches Facility. Addendum I-Probabilistic Monte Carlo Simulation. August 10, 1992.

11. U.S. Environmental Protection Agency (EPA), 1983. Health and Environmental Effects Profile for 1,3-Butadiene. EPA/60/0-84/120. May, 1983.

12. U.S. Environmental Protection Agency (EPA), 1985. Mutagenicity and Carcinogenic Assessment of 1,3-Butadiene. EPA/600/8/85-004f.

13. U.S. Environmental Protection Agency (EPA), 1987. Industrial Source Complex (ISC) Dispersion Model. Addendum to User's Guide. 1987.

14. U.S. Environmental Protection Agency (EPA), 1989. Risk Assessment Guidance for Superfund. Volume 1 Human Health Education Manual (Part A). Interim Final. EPA 540/1-89-002. December, 1989.

15. U.S. Environmental Protection Agency (EPA), 1991. Risk Assessment Guidance for Superfund. Volume 1 Human Health Evaluation Manual. Supplemental Guidance. Standard Default Exposure Factors. March 25, 1991.

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Front Matter (R1-R16)
Executive Summary (1-15)
1 Introduction (16-22)
Part I Current Approaches to Risk Assessment: 2 Risk Assessment and its Social and Regulatory Contexts (23-42)
3 Exposure Assessment (43-55)
4 Assessment of Toxicity (56-67)
5 Risk Characterization (68-78)
Part II Strategies for Improving Risk Assessment: 6 Default Options (79-105)
7 Models, Methods, and Data (106-143)
8 Data Needs (144-159)
9 Uncertainty (160-187)
10 Variability (188-223)
11 Aggregation (224-242)
Part III Implementation of Findings: 12 Implementation (243-268)
References (269-286)
Appendix A: Risk Assessment Methodologies: EPA (287-350)
Appendix B: EPA Memorandum from Henry Habicht (351-374)
Appendix C: Calculation and Modeling of Exposure (375-382)
Appendix D: Working Paper for Considering Draft Revisions to the U.S. EPA Guidelines for Cancer Risk Assessment (383-448)
Appendix E: Use of Pharmacokinetics to Extrapolate from Animal Data to Humans (449-452)
Appendix F: Uncertainty Analysis of Health Risk Estimates (453-478)
Appendix G: Improvement in Human Health Risk Assessment Utilizing Site- and Chemical-Specific Information: A Case Study (479-502)
Appendix H-1: Some Definitional Concerns About Variability (503-504)
Appendix H-2: Individual Susceptibility Factors (505-514)
Appendix I: Aggregation (515-536)
Appendix J: A Tiered Modeling Approach for Assessing the Risks Due to Sources of Hazardous Air Pollutants (537-582)
Appendix K: Science Advisory Board Memorandum on the Integrated Risk Information System and EPA Response (583-590)
Appendix L: Development of Data Used in Risk Assessment (591-598)
Appendix M: Charge to the Committee (599-600)
Appendix N-1: The Case for (601-628)
Appendix N-2: Making Full Use of Scientific Information in Risk Assessment (629-640)
Index (641-652)