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Science and Judgment in Risk Assessment (1994)
Board on Environmental Studies and Toxicology (BEST)

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. "Appendix N-2: Making Full Use of Scientific Information in Risk Assessment." Science and Judgment in Risk Assessment. Washington, DC: The National Academies Press, 1994.

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Page 640

lution of the uncertainties are likely to change decisions, leading to substantial benefits in improved public health and reduced control costs (OTA, 1993). More targeted research designed to avoid costly regulations based on conservative default options in risk assessment should pay very large economic dividends, while at the same time allowing better management of the substances that do present substantial risks to public health.

References

EPA (U.S. Environmental Protection Agency). 1986. Guidelines for carcinogen risk assessment. Fed. Regist. 51:33992-34003.

EPA (U.S. Environmental Protection Agency). 1989. Letter report to EPA administrator, William Reilly, from the Science Advisory Board, Nov. 28. SAB-EC-90-003. U.S. Environmental Protection Agency, Washington, D.C.

Howard, R.A., J.E. Matheson, and D.W. North. 1972. The decision to seed hurricanes. Science 176:1191-1202.

NRC (National Research Council). 1983. Risk Assessment in the Federal Government: Managing the Process. Washington, D.C.: National Academy Press.

OTA (U.S. Office of Technology Assessment). 1993. Researching Health Risks. U.S. Office of Technology Assessment, Washington, D.C.

Whitfield, R.G., and T.S. Wallsten. 1989. A risk assessment for selected lead-induced health effects: An example of a general methodology. Risk Anal. 9:197-207.

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Front Matter (R1-R16)
Executive Summary (1-15)
1 Introduction (16-22)
Part I Current Approaches to Risk Assessment: 2 Risk Assessment and its Social and Regulatory Contexts (23-42)
3 Exposure Assessment (43-55)
4 Assessment of Toxicity (56-67)
5 Risk Characterization (68-78)
Part II Strategies for Improving Risk Assessment: 6 Default Options (79-105)
7 Models, Methods, and Data (106-143)
8 Data Needs (144-159)
9 Uncertainty (160-187)
10 Variability (188-223)
11 Aggregation (224-242)
Part III Implementation of Findings: 12 Implementation (243-268)
References (269-286)
Appendix A: Risk Assessment Methodologies: EPA (287-350)
Appendix B: EPA Memorandum from Henry Habicht (351-374)
Appendix C: Calculation and Modeling of Exposure (375-382)
Appendix D: Working Paper for Considering Draft Revisions to the U.S. EPA Guidelines for Cancer Risk Assessment (383-448)
Appendix E: Use of Pharmacokinetics to Extrapolate from Animal Data to Humans (449-452)
Appendix F: Uncertainty Analysis of Health Risk Estimates (453-478)
Appendix G: Improvement in Human Health Risk Assessment Utilizing Site- and Chemical-Specific Information: A Case Study (479-502)
Appendix H-1: Some Definitional Concerns About Variability (503-504)
Appendix H-2: Individual Susceptibility Factors (505-514)
Appendix I: Aggregation (515-536)
Appendix J: A Tiered Modeling Approach for Assessing the Risks Due to Sources of Hazardous Air Pollutants (537-582)
Appendix K: Science Advisory Board Memorandum on the Integrated Risk Information System and EPA Response (583-590)
Appendix L: Development of Data Used in Risk Assessment (591-598)
Appendix M: Charge to the Committee (599-600)
Appendix N-1: The Case for (601-628)
Appendix N-2: Making Full Use of Scientific Information in Risk Assessment (629-640)
Index (641-652)