increasing cell proliferation rates puts cells at increased risk of carcinogenesis from spontaneous mutation. Until a dose of such a carcinogen sufficient to cause the necessary toxicity or intracellular response is reached, no significant risk of cancer can exist. Such carcinogens, or their metabolites, show little or no propensity to damage genes (they are nongenotoxic).
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4 Assessment of Toxicity ."
Science and Judgment in Risk Assessment . Washington, DC: The National Academies Press,
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