Agricultural Research Service (ARS), 209-210, 216

Airborne exposure

indoor, 309-311

outdoor, 308-309

Alachlor, 246

in water, 228-229, 230, 232

Albumin, 86-87

Alcohol exposure, 61, 77

Aldicarb, 227, 246, 270, 287

cholinesterase inhibition, 53, 287-288

dietary exposure, 288-296

immunotoxicity, 66-67, 69

testing for, 253

in water, 226

Aldrin, 14.

See also Dieldrin

Alveolar epithelium, 79

Aminocarb, 67

Amphetamines, pesticide interactions, 348

Androgens, 28

Anemia

animal studies, 29-30

aplastic, 311

and poverty, 343

Anesthetics, 56

Animal models and studies, 107, 360, 362

acute effects, 50-53, 130, 133, 136, 334-335, 344

brain development, 25, 26, 60

carcinogenesis, 34, 41-42, 70-75, 145-146, 334-338, 344-345

chronic effects, 145-146, 154

developmental toxicity, 4, 9, 29-32, 43-44, 146-147

end points, 52, 153

extrapolation of, 20, 25, 43, 76-77, 96-102, 110, 324-328, 335-338, 360, 361

guidelines, 109, 129-131, 152-156

immunotoxicity, 9, 66-68

LD₅₀ studies, 50-53, 334-335, 344

metabolism, 150-151, 153

mutagenicity, 128, 150

neurotoxicity, 9, 65-66, 128, 151-152, 155-156

reproductive toxicity, 9, 128, 147-149, 155

scaling, 96-102, 97-99, 110, 337

subchronic effects, 130, 137, 144-145

TD₅₀ studies, 334-335

uncertainty factors, 9, 325-328, 360, 361

Anticancer drugs, 57-59, 75

Anticonvulsants, 56-57

Antihistamines, pesticide interaction, 348

Aplastic anemia, and chlordane, 311

Apples, 248, 254, 256

juices, 249, 353-357

pesticide use, 273, 275

processed products, 259

Application rates and methods, 13, 14-16, 203-204

aerial, 308-309

and exposure estimates, 317, 318

geographic variations, 204-206, 228, 317

and sampling variation, 224, 226-227

see also Field trials

Arsenicals, 14

Arylesterase, 54, 346

Atherosclerosis, 344

Atrazine, 246

in water, 228, 229, 230, 232

Autocrine mechanisms, 28

Average daily intakes, 6, 11, 271-272, 315, 317

Azidothymidine (AZT), 59-60

Azinphos, 273

B

Bananas, aldicarb residues, 289-296

Behavioral function, 24, 32, 62

low-level exposure and effects, 63-64, 65

Benchmark dose, 338, 362

Benomyl, 244, 246, 269, 277

FRONT MATTER (R1-R15)

EXECUTIVE SUMMARY (1-12)

1 BACKGROUND AND APPROACH TO THE STUDY (13-22)

2 SPECIAL CHARACTERISTICS OF CHILDREN (23-48)

3 PERINATAL AND PEDIATRIC TOXICITY (49-126)

4 METHODS FOR TOXICITY TESTING (127-158)

5 FOOD AND WATER CONSUMPTION (159-202)

6 PESTICIDE RESIDUES (203-266)

7 ESTIMATING EXPOSURES (267-322)

8 ESTIMATING THE RISKS (323-372)

INDEX (373-386)