by multiplying the actual level of each pesticide residue by its toxicity equivalence factor and summing the results. This information may be combined with data on consumption to construct a distribution of total exposure to all pesticides having a common mechanism of action. To test this multiple-residue methodology, the committee estimated children's acute health risks resulting from combined exposure to five members of the organophosphate insecticide family. This was accomplished by combining actual food consumption data with data on actual pesticide residue levels.

Through this new analytical procedure, the committee estimated that for some children, total organophosphate exposures may exceed the reference dose. Furthermore, although the data were weak, the committee estimated that for some children exposures could be sufficiently high to produce symptoms of acute organophosphate pesticide poisoning.

Compared to late-in-life exposures, exposures to pesticides early in life can lead to a greater risk of chronic effects that are expressed only after long latency periods have elapsed. Such effects include cancer, neurodevelopmental impairment, and immune dysfunction. The committee developed new risk assessment methods to examine this issue.

Although some risk assessment methods take into account changes in exposure with age, these models are not universally applied in practice. The committee explored the use of newer risk assessment methods that allow for changes in exposure and susceptibility with age. However, the committee found that sufficient data are not currently available to permit wide application of these methods.


On the basis of its findings, the committee recommends that certain changes be made in current regulatory practice. Most importantly, estimates of expected total exposure to pesticide residues should reflect the unique characteristics of the diets of infants and children and should account also for all nondietary intake of pesticides. Estimates of exposure should take into account the fact that not all crops are treated with pesticides that can be legally applied to those crops, and they should consider the effects of food processing and storage. Exposure estimates should recognize that pesticide residues may be present on more than one food commodity consumed by infants and children and that more than one pesticide may be present on one food sample. Lastly, determinations of safe levels of exposure should take into consideration the physiological factors that can place infants and children at greater risk of harm than adults.

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