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Adverse Events Associated with Childhood Vaccines: Evidence Bearing on Casuality (1994)
Institute of Medicine (IOM)

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. "5 Diphtheria and Tetanus Toxoids ." Adverse Events Associated with Childhood Vaccines: Evidence Bearing on Casuality. Washington, DC: The National Academies Press, 1994.

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Adverse Events Associated with Childhood Vaccines: Evidence Bearing on Causality

Study; Vaccines

Hypotension

Wheezing

Upper Airway Obstruction

Other

Epinephrine

Analphylaxis

Whittingham, 1940; tetanus

?

? Dyspnea

?

Improved in 20 min

Yes

Yes; skin test +; Witte peptone

Whittingham, 1940; tetanus

No

? Dyspnea

?

Normal in 15 min

Yes

Yes; skin test +; Witte peptone

Parish and Oakley, 1940; tetanus

No

No

No

Back, abdominal pain

Yes

Yes

Regamey, 1965; tetanus

?

?

?

Immunized in 1933; Death/autopsy; "extreme bronchospasm"

No

Yes

Staak and Wirth, 1973; tetanus

?

No

?

Death/autopsy: peribronchial eosinophils

No

Yes

Lleonart-Bellfill et al., 1991: tetanus; typhoid

Yes

? Dyspnea

No

3 mo later serum IgE increased; skin test: tetanus +, typhoid

Yes

Yes

Ratliff and Bums-Cox, 1984; tetanus and lignocaine

?

Yes

?

Respiratory arrest; asystole seizures; recovered

Yes

Yes

Zaloga and Chernow, 1982; tetanus

Yes

Yes

Yes

Normal in 24 h

Yes

Yes

Chanukoglu et al.,a 1975; tetanus

Yes

Yes

?

Vomiting; normal in 24 h

Yes

Yes

Fischmeister, 1974; tetanus

?

Yes

Yes

Normal in 10 min; edema, itching 12 days later

No; prednisone calcium

Yes

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