Table 5-1. One of the 13 cases of anaphylaxis from 1933 was described in a review by Regamey (1965). Three occurred in 1940 and were presumed (by skin testing) to be related to contamination of the vaccine by Witte peptones (Parish and Oakley, 1940; Whittingham, 1940). Two deaths occurred in association with tetanus toxoid administered as a single antigen. In the 1965 review, Regamey reported a fatality in a 20-year-old man 2 hours after he received his third tetanus toxoid injection. This patient had a history of an episode of collapse and convulsions after receiving his second dose of tetanus toxoid. In 1973, Staak and Wirth reported the death of a 24-year-old woman 30 minutes after receiving an injection of tetanus toxoid.