. "6 Measles and Mumps Vaccines ." Adverse Events Associated with Childhood Vaccines: Evidence Bearing on Casuality. Washington, DC: The National Academies Press, 1994.
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Adverse Events Associated with Childhood Vaccines: Evidence Bearing on Causality
FIGURE 6-1 Derivation of measles vaccine strains. Sources: Adapted from Plotkin and Mortimer (1988, p. 189) and Hirayama M. (1983).
ated Enders strain vaccine is currently in use in the United States; the Schwarz strain is used elsewhere in the world. Other strains have been developed and used in various smaller population groups. 'Figure 6-1 illustrates the derivation of many measles vaccines from the Edmonston strain. Table 6-1 lists the measles vaccines used in the United States.
TABLE 6-1
Measles Vaccines Used in the United States
Attenuation
Strain
Trade Name
Manufacturer
Years in Use
Live attenuated
Edmonston B
Rubeovax
Merck Sharpe & Dohme
1963-1975
M-Vac
Lederle
1963-1975
Pfizer-vax;
Pfizer
1963-1975
Measles-L
Generic
Lilly, Parke Davis, Philips Roxane
1963-1975
Live, more attenuated
Schwarz (derived from Edmonston A)
Lirugen
Pitman Moore-Dow
1965-1976
More-attenuated Enders (derived from Edmonston B)
Attenuvax
Merck Sharp & Dohme
1968-presen
Source: Adapted from Plotkin and Mortimer (1988, p. 189).