FIGURE 6-1 Derivation of measles vaccine strains. Sources:  Adapted from Plotkin and Mortimer (1988, p. 189) and Hirayama M. (1983).

ated Enders strain vaccine is currently in use in the United States; the Schwarz strain is used elsewhere in the world. Other strains have been developed and used in various smaller population groups. 'Figure 6-1 illustrates the derivation of many measles vaccines from the Edmonston strain. Table 6-1 lists the measles vaccines used in the United States.

TABLE 6-1

Measles Vaccines Used in the United States

Attenuation

Strain

Trade Name

Manufacturer

Years in Use

Live attenuated

Edmonston B

Rubeovax

Merck Sharpe & Dohme

1963-1975

 

 

M-Vac

Lederle

1963-1975

 

 

Pfizer-vax;

Pfizer

1963-1975

 

 

Measles-L

 

 

 

 

Generic

Lilly, Parke Davis, Philips Roxane

1963-1975

Live, more attenuated

Schwarz (derived from Edmonston A)

Lirugen

Pitman Moore-Dow

1965-1976

 

More-attenuated Enders (derived from Edmonston B)

Attenuvax

Merck Sharp & Dohme

1968-presen

 

Source: Adapted from Plotkin and Mortimer (1988, p. 189).



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