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Adverse Events Associated with Childhood Vaccines: Evidence Bearing on Causality
Guillain-Barré syndrome, 87 , 151 , 216 , 219 , 244 , 246
immunosuppression, 64
multiple sclerosis, 36 , 220
neuropathy, 90-91
optic neuritis, 147-148
orchitis, 160-161 , 163
poliomyelitis, 191
residual seizure disorder, 79 , 142
sensorineural deafness, 146
subacute sclerosing panencephalitis, 136
thrombocytopenia, 164-165 , 248
transverse myelitis, 149 , 196 , 199 , 242
Brachial neuritis, 54-55
causality, 16 , 93-94
diphtheria-tetanus vaccination and, 16 , 90 , 91 , 92 , 93-94
C
Campylobacter jejuni , 39
Canada, 131 , 132 , 144 , 161 , 166 , 173
Case-control studies, 29
Case reports and uncontrolled studies, 5
absence of, 22
anaphylaxis, 104-108 , 171-175 , 229 , 262
arthritis, 95-97 , 224-226
aseptic meningitis, 131-134
brachial neuritis, 91-92
data sources, 23 , 28-29
demyelinating diseases, 84-85 , 221
diabetes mellitus, 156-158
early-onset Hib disease, 253-254 , 256-260
encephalopathy, 74-75 , 123-129
erythema multiforme, 98-99
evaluation of, 23-26
fatal outcomes, 275 , 287-289 , 291-294 , 296-298 , 300 , 301
Guillain-Barré syndrome, 87-88
infantile spasms, 81
mononeuropathy, 91
multiple sclerosis, 221
optic neuritis, 85 , 148 , 221
orchitis, 161-162
poliomyelitis, 190 , 191-194
residual seizure disorder, 79-81 , 142-145
role of, 22
sensorineural deafness, 146
subacute sclerosing panencephalitis, 136-138
thrombocytopenia, 165-167 , 248-249
transverse myelitis, 149-150 , 198-199 , 242
Causality
anaphylaxis, 16 , 17 , 108 , 109 , 110 , 175-176 , 205 , 230-231 , 262-263
arthritis/arthropathy, 97 , 226-227
aseptic meningitis, 134-135
brachial neuritis, 16 , 93-94
Can It? assessment, 20-23
categories of, 16-17 , 32-33
combination vaccines, 5
definitions, 19-20
demyelinating diseases, 47-48 , 85-86 , 222
diabetes mellitus, 159
Did It? assessment, 20 , 23-26
early-onset Hib disease, 260-261
encephalopathy, 16 , 77-78 , 129-130
erythema multiforme, 99
evidence for determination of, 5 , 22-23 , 27-33
fatal outcomes, 16 , 17 , 109-110 , 205-206 , 231 , 263 , 276-277 , 277-278 , 289-290 , 294-295 , 298-299 , 300-301 , 302
focal lesions, 36-37
Guillain-Barré syndrome, 16 , 17 , 88-89 , 109 , 110 , 153 , 203-204 , 219 , 246
Haemophilus influenzae type b, 16 , 17
infantile spasms, 16 , 17 , 82
Koch's postulates, 19
measles vaccine-strain viral infection, 17 , 176-177 , 291 , 294-295
mononeuropathy, 54 , 93 , 94