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Adverse Events Associated with Childhood Vaccines: Evidence Bearing on Casuality (1994)
Institute of Medicine (IOM)

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. "1 Executive Summary." Adverse Events Associated with Childhood Vaccines: Evidence Bearing on Casuality. Washington, DC: The National Academies Press, 1994.

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Adverse Events Associated with Childhood Vaccines: Evidence Bearing on Causality

TABLE 1-1

Summary of the Evidence For or Against a Determination of a Causal Relationa

Vaccine and Adverse Event

Biologic Plausibilityb

Case Reports, Case Series, and Uncontrolled Observational Studies

Controlled Observational Studies and Controlled Clinical Trials

Diphtheria and Tetanus Toxoidsc

 

 

 

Encephalopathy

Demonstrated

Indeterminate

Against (DT) No data (Td, T)

Infantile spasmsd (DT only)

Theoretical only

No data

Against

Residual seizure disorders other than infantile spasms

Theoretical only

Indeterminate (DT, T) No data (Td)

No data

Demyelinating diseases of the central nervous system

Demonstrated

For

No data

Guillain-Barré syndrome

Demonstrated

For (T) Indeterminate (DT, Td)

No data

Mononeuropathy

Theoretical only

Indeterminate (T, Td)No data (DT)

No data

Brachial neuritis

Theoretical only

For (T) Indeterminate (Td) No data (DT)

No data

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