NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance.

This report has been reviewed by a group other than the authors according to procedures approved by a Report Review Committee consisting of members of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine.

The Institute of Medicine was chartered in 1970 by the National Academy of Sciences to enlist distinguished members of the appropriate professions in the examination of policy matters pertaining to the health of the public. In this the Institute acts under the Academy’s 1863 congressional charter responsibility to be an adviser to the federal government and, upon its own initiative, to identify issues of medical care, research, and education. Dr. Kenneth I. Shine is President of the Institute of Medicine.

The project was supported by funds coordinated through the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (contract no. NO1-AI-15130).

Library of Congress Cataloging-in-Publication Data

Adverse events associated with childhood vaccines : evidence bearing on causality / Kathleen R. Stratton, Cynthia J. Howe, and Richard B. Johnston, Jr., editors ; Division of Health Promotion and Disease Prevention, Institute of Medicine.

p. cm.

“The project was supported by funds coordinated through the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (contract no. NO-AI-15130)”—T.p. verso.

Includes bibliographical references and index.

1. Vaccination of children—Complications. 2. Vaccines—Health aspects. 3. Vaccines—Toxicology. I. Stratton, Kathleen R. II. Howe, Cynthia J. III. Johnston, Richard B., 1935- . IV. Institute of Medicine (U.S.). Division of Health Promotion and Disease Prevention. V. National Institute of Allergy and Infectious Diseases (U.S.).

[DNLM: 1. Vaccines—adverse effects. 2. Immunization—in infancy & childhood. WS 135 A244 1993]

RJ240.A38 1993

615'.372'083—dc20

DNLM/DLC 93-32099

for Library of Congress CIP

The serpent has been a symbol of long life, healing, and knowledge among almost all cultures and religions since the beginning of recorded history. The serpent adopted as a logotype by the Institute of Medicine is a relief carving from ancient Greece, now held by the Staatlichemuseen in Berlin.