This report presents the findings from all the aforementioned methods of data collection and analysis. The following chapters elaborate on the issues the committee explored, presents its findings and conclusions, and offers its recommendations for improving clinical research career pathways. Chapter 2 examines the employment sectors and issues and obstacles confronting established clinical investigators, with an emphasis on academic clinical investigators. Chapter 3 discusses the available resources for funding clinical research. The obstacles and barriers to training pathways are presented in Chapter 4. Chapter 5 explores the academic-industry relationships and the roles and responsibilities of investigators in these alliances.