. "B1. 1993: RU 486--A Decade on Today and Tomorrow." Clinical Applications of Mifepristone (RU486) and Other Antiprogestins: Assessing the Science and Recommending a Research Agenda. Washington, DC: The National Academies Press, 1993.
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Clinical Applications of Mifepristone (RU 486) and other Antiprogestins: Assessing the Science and Recommending a Research Agenda
TABLE B1.4 Uses of RU 486
5–9 weeks of amenorrhea
Occasional luteal contragestion
Once-a-month menses induction
Suppression of ovulation
Medical Interruption of Pregnancy
observations made in vitro, as discussed above.
Thus, administration of RU 486 may produce effects in different directions, which have to be studied separately in each tissue. However, to provoke abortion or trigger labor, the effects on the decidua, endometrium, cervix, and even the trophoblast combine to make RU 486 a very efficient agent for the termination of pregnancy.
REPRODUCTIVE MEDICINE (TABLE B1.4)
Voluntary Early Pregnancy Interruption
On the basis of animal experiments, we expected RU 486 to meet the recognized need for an efficient medical means of early abortion, to be safer than a surgical technique, and to be relatively convenient and cheap (no anesthesia, no operating room). To develop a medical method of abortion was a must in terms of women's health and potentially a step toward more privacy for those having taken the difficult decision of pregnancy termination.
Early abortion offered the first opportunity to test RU 486 activity in