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APPENDIX 2 LeHer to AF!P

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Appendix 17S NATIONAL RESEARCH COUNCIL I3OARD ON ENVIRONMENTAL STUDIES AND TOXICOLOGY 2101 Co~lstittitio~l A`re~ll~t, Waslli~lytt,il, D.C. 20418 COM\lIT1 EE C)N' T(]XICOI OGY Colonel John M. Pletcher Department of Veterinary Pathology Armed Forces Institute of Pathology Washington, DC 20306-6000 Dear Col. Pletcher: July 24, 1992 The National Research Council's Committee on Toxicology has organized the Subcommittee on Risk Assessment of Ingested Fluoride. This study was requested by the U.S. Environmental Protection Agency to determine if the current drinking water standard for fluoride (4 mg/L) is appropriate. At its second meeting on July 13, 1992, in Aspen, CO, the subcommittee recommended the review of Procter and Gamble's mouse fluoride carcinogenicity study by the Armed Forces Institute of Pathology (AFIP) for the following: What is the proper terminology for these lesions? Should the osteomas be considered neoplasms? Is there a hyperostosis/osteoma continuum? Do the osteomas have potential for malignant change? Would these lesions regress if the stimulus were removed? How often are bone neoplasms in animals multicentric? Is there a human counterpart for these lesions? Of those people involved, there is general knowledge of a contaminating virus in this mouse study. What evidence is available to confirm it? We have requested Procter and Gamble to submit mouse slides to AFIP for its independent review. The final meeting of the subcommittee is scheduled for October 16, 1992, in Washington, DC. Therefore, it would be helpful if you could review the slides as soon as possible and have your report prior to the October 16 meeting. Tl/i .\t,~ti`~n,71 RL'S{'/7/ t l/ Ct,nn~-il is flu I,/ in. i/,,71 t4','n7tin< /7g`'n~!/ Of tl/t .N',itit,nal .Ai ,7,1, A/!/ t,! St it nt ~ s ,7/u{ flu ,~,?tit,n,rl . l.-.7,z~ A/!/ (]f hngint ~ / ing try se/ At gr7Z'r'/ n'ut'ut 0/u1 title/ t7/guni:atit,'/s. Tin- Bi,,7/,1 fin C//z~i/ t7/nut nti71 Stu`lit s ,7/ul Try rit t~li'V!/ ii n sl ~i,n5il~lt try tall- N/,7titinu1 Rt st,7/ i-l/ Ci7/n~-il tin t'ugl/ flu- Ct,/innissli,n 4~// 1.//r Stit //t-t s ,7//~1 tl/t Cti,/////iisi`~// If// Gi fist it 'rt ~ s. F//;'i/,',////t lit. `~//,1 Rt sti///-t ~ s. TEI: (2()2) 334-26]6 I:AX: (2()2) 334-1393

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176 Health Effects of Ingested Fluoride We highly appreciate your willingness to review the mouse slides for us. With best regards, I am, Sincerely, kin ~ F:~ Kulbir S. Bakshi, Ph.D. Project Director KSB/cmk