adding the twist of supplementing a very low protein diet with essential amino acids. The most recent studies (1988) suggest a decisive role for glomerular hypertrophy in the pathogenesis of the end-stage kidney.

In 1981 Rytand and Spreiter published a forty-fifty-year follow-up study of patients with orthostatic proteinuria who were first seen by Addis and Rytand.30


Sources consulted for this memoir include several former colleagues of Tom Addis: L. J. Rather, D. A. Rytand, R. Cohn, M. Krupp, L. Bayer, and B. Scribner.

Written references include the following:

D. A. Rytand, Medicine and the Stanford University School of Medicine, Circa 1932: The Way it Was . (Department of Medicine and Alumni Association, Stanford University School of Medicine, 1984).

"Festschrift for Thomas Addis," Stanford Medical Bulletin, 6 (February 1948).

A. L. Bloomfield, Stanford Medical Bulletin, 16 (August 1958).

L. J. Rather, Stanford Medical Bulletin, 17 (1959).

H. W. Smith, The Kidney—Structure and Function in Health and Disease (New York: Oxford University Press, 1951).

A. M. Harvey, "Classics in Clinical Science: The Concept of Clearance," American Journal of Medicine, 68(1980):6–7.

A. M. Harvey, Science at the Bedside: Clinical Research in American Medicine, 1905–1945 (Baltimore: Johns Hopkins Univ. Press, 1981):386–87.

H. B. Shumacher, Leo Eloesser, M.D.: Eulogy for a Free Spirit (New York: Philosophical Library, 1982).

S. J. Peitzman, Thomas Addis (1881–1949): Mixing Patients, Rats, and Politics. Kidney International (in Press).

We thank Betty Vadeboncoeur for her help.

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