TABLE 3-2 Appetite-Suppressing Drugs

Noradrenergic Agents

DEAa Schedule

Trade Name

Half-Life (hours)

Dosage Size (mg)

Daily Dose Range (mg)

Benzphetamine

III

Didrex

6–12

25; 50

25–150

Phendimetrazine

III

Anorex; Obalan; Phendiet; Plegine; Wehless; and others

5–12

35

70–210

Diethylpropion

IV

Tenuate; Tepanol

4–6

25; 75 (slow release)

75

Mazindol

IV

Mazanor; Sanorex

10

1 or 2

1–3

Phentermine

IV

Fastin; Ionamin; Phentrol; Adipex-P; and others

12–24

8; 15; 30

15–37.5

Phenylpropanolamine

Over the counter

Dexatrim

7–24

25 or 75

25–75

Serotonergic agents

Fenfluramine (d- or d-l)

IV

Pondimin

11–30

20

60–120

Fluoxetine

Not scheduled

Prozac; Lovan

24–72

20; 60

60

a DEA = Drug Enforcement Agency. See box titled ''Unreasonable Standards for Anti-Obesity Drugs?" for an explanation of the schedule classification.

SOURCE: Reproduced with permission, from G.A. Bray. Use and abuse of appetite-suppressant drugs in the treatment of obesity. Ann. Intern. Med. 1993;119:707–713.



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