FIGURE 6.7 NIAAA Non-AIDS Funding by Mechanism, 1987–1992. Source: NIAAA Budget Office.

(2) alcohol and immune system development to understand the possible role of alcohol as a cofactor of maternal transmission of HIV; (3) alcohol and cellular and humoral immunity to understand mechanisms of alcohol's effects on host resistance to HIV and related infections; (4) alcohol and neurohormonal immunomodulation to understand interactions between the nervous, endocrine, and immune systems; and (5) the murine AIDS model, which is used to understand how the virus attacks the immune system, and to test treatment modalities.

The NIAAA intramural research program primarily has focused on (1) alcohol's potential role as a cofactor in the etiology of AIDS and as a promotor of opportunistic infection in patients suffering from AIDS; (2) the effects of HIV on neuronal function; and (3) the basic mechanisms underlying lymphocyte immunosuppression. Selected research includes studies on the factors controlling T-cell maturation and proliferation, the effects of HIV proteins and related viral coat proteins on neuronal function, and the mechanisms



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