1989 through FY 1992. IOM staff cross-checked these lists against all CRISP abstracts received and both of these sets of information against the institutes' historical budget tables for each fiscal year. Although minor discrepancies were found, IOM staff worked with the AIDS offices and the budget offices of each institute to address them and to ensure that the committee ultimately had access to a complete set of AIDS-related grant abstracts with accurate information. Remaining discrepancies are described in the database section, below.

The CRISP files for each AIDS research grant funded by NIAAA, NIDA, and NIMH contained detailed information identifying the principal investigator, institution, project title, project summary abstract, IRG code, program class code, years of funding, and amounts paid in each year. The identification number for each grant (which also appears on the CRISP file) includes: an activity type code to identify the type of application received and processed (e.g., new and competing); an activity code (e.g., funding mechanism) to identify the category of research (e.g., R01); the institute, center, or division (ICD) code to identify the institute (AA = NIAAA; DA = NIDA; MH = NIMH); a five-digit serial number; and suffixes to identify other relevant information such as the grant year. CRISP files for contracts provide the total funding commitment without a breakdown of spending for each fiscal year, whereas CRISP files for intramural research do not provide funding information.

To guide the analysis of the grants data, the IOM staff and committee also reviewed and referred to a number of documents, including formal and informal budget documents, "Moyer Reports" (FY 1989 through FY 1993), AIDS Expenditure Reports from HHS, the NIMH Strategic Plan for AIDS Research (1993–1998), the NIMH AIDS Research Blueprint for the Second Decade, the NIMH HIV Prevention Highlights, the NIMH Handbook on Developing a Successful Research Application, the NIDA Five-Year Strategic Plan, a variety of documents describing program initiatives at all three institutes, and all program announcements (PAs), requests for applications (RFAs), and requests for proposals (RFPs) issued by NIAAA, NIDA, and NIMH since FY 1983.

DATABASE

To facilitate the grants analysis, IOM staff created a database using the Paradox database management system. A form was developed to record pertinent information for each AIDS grant and contract (Box A.1). In addition to information tracked by the



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