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. "FRONT MATTER." Biologic Markers in Urinary Toxicology. Washington, DC: The National Academies Press, 1995.
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4
BIOLOGIC MARKERS OF EFFECT
81
External Visualization
82
Urinary Clearance Measurements
Urinalysis
85
Markers of Cytotoxicity and Cellular Response
95
Markers of Neoplasia
103
Markers of Interstitial Cystitis
114
Summary
116
5
BIOLOGIC MARKERS IN EXTRAPOLATION
153
Basis of Extrapolation
156
Techniques Used in Risk Assessment
166
Improved Risk-Assessment Extrapolation
180
187
6
NEW TECHNOLOGIES
191
Markers of Cell Injury, Regeneration, and Hypertrophy
Cancer of the Bladder
199
Differential-Display Polymerase Chain Reaction
202
Cancer of the Prostate
203
Cancer of the Kidney
207
7
CONCLUSIONS AND RECOMMENDATIONS
217
Toxic Exposure of the Urinary Tract
Biologic Markers of Exposure and Susceptibility
220
Biologic Markers of Effect
221
Use of Biologic Makers in Extrapolation
223
New Technologies
224
REFERENCES
227