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FIAC:

fiacitabine, a pyrimidine nucleoside analog originally synthesized by Fox and his colleagues at Memorial Sloan-Kettering cancer center to be used in the treatment of herpes group virus infections (See figure 1, chapter 4)

FIAU:

fialuridine, the principal metabolite of FIAC, also a pyrimidine nucleoside analog

flare:

a rise in serum aminotransferases (AST and/or ALT) prior to normalization of liver enzymes, frequently associated with clearance of hepatitis B virus from the liver


Gilbert's syndrome:

an inborn error of bilirubin metabolism, probably autosomal dominant, a benign elevation of unconjugated bilirubin with no liver damage or hematologic abnormalities

glomerulonephritis:

a variety of nephritis (inflammation of the kidney) characterized by inflammation of the capillary loops in the glomeruli of the kidney


half-life:

the time that it takes for the concentration of drug in plasma or the amount of drug in the body to be reduced by 50 percent

HBV:

hepatitis B virus

HCC:

hepatocellular carcinoma

HCV:

hepatitis C virus

hepatic steatosis:

fatty deposits in the liver

hepatocellular steatosis:

fatty deposits within or around hepatocytes

hepatocyte:

a parenchymal liver cell, an essential element of the organ

hepatotoxicity:

the quality or property of exerting a destructive or poisonous effect liver cells

HIV:

human immunodeficiency virus

hyperbilirubinemia:

excessive concentrations of bilirubin in the blood, which may lead to jaundice

hypoalbuminemia:

an abnormally low albumin content of the blood

H3X-MC-PPPA:

FIAU study conducted on five hepatitis B virus-positive subjects at the New England and Galveston sites, sponsored by Eli Lilly. Referred to in this report as Trial PPPA.

H3X-MC-PPPC:

FIAU study conducted on 15 hepatitis B virus-positive subjects at the National Institutes of Health Clinical Center, sponsored by Eli Lilly. Referred to in this report as Trial PPPC.

H3X-MC-PPPG:

FIAU study conducted on 17 healthy males at the Lilly Laboratory for Clinical Research, sponsored by Eli Lilly. Referred to in this report as Trial PPPG.


ICD:

informed consent document

IND:

investigational new drug application

interferon:

a naturally occurring protein produced by lymphocytes and fibroblasts in response to chronic viral infection which has been used in the treatment of chronic hepatitis B virus infection since the 1970s

IRB:

institutional review board


jaundice:

yellowish skin



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