fiacitabine, a pyrimidine nucleoside analog originally synthesized by Fox and his colleagues at Memorial Sloan-Kettering cancer center to be used in the treatment of herpes group virus infections (See figure 1, chapter 4)
fialuridine, the principal metabolite of FIAC, also a pyrimidine nucleoside analog
a rise in serum aminotransferases (AST and/or ALT) prior to normalization of liver enzymes, frequently associated with clearance of hepatitis B virus from the liver
an inborn error of bilirubin metabolism, probably autosomal dominant, a benign elevation of unconjugated bilirubin with no liver damage or hematologic abnormalities
a variety of nephritis (inflammation of the kidney) characterized by inflammation of the capillary loops in the glomeruli of the kidney
the time that it takes for the concentration of drug in plasma or the amount of drug in the body to be reduced by 50 percent
hepatitis B virus
hepatitis C virus
fatty deposits in the liver
fatty deposits within or around hepatocytes
a parenchymal liver cell, an essential element of the organ
the quality or property of exerting a destructive or poisonous effect liver cells
human immunodeficiency virus
excessive concentrations of bilirubin in the blood, which may lead to jaundice
an abnormally low albumin content of the blood
FIAU study conducted on five hepatitis B virus-positive subjects at the New England and Galveston sites, sponsored by Eli Lilly. Referred to in this report as Trial PPPA.
FIAU study conducted on 15 hepatitis B virus-positive subjects at the National Institutes of Health Clinical Center, sponsored by Eli Lilly. Referred to in this report as Trial PPPC.
FIAU study conducted on 17 healthy males at the Lilly Laboratory for Clinical Research, sponsored by Eli Lilly. Referred to in this report as Trial PPPG.
informed consent document
investigational new drug application
a naturally occurring protein produced by lymphocytes and fibroblasts in response to chronic viral infection which has been used in the treatment of chronic hepatitis B virus infection since the 1970s
institutional review board