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the informed consent form and finds it to be of generally high quality, but noted that it did not include specific reference to the clinical manifestations of peripheral neuropathy. The patient who developed peripheral neuropathy recalled that during the last or penultimate scheduled visit he happened to mention to the study nurse numbness in his toes, which he attributed to wearing ''flip-flops.'' She insisted on setting up an appointment with a neurologist to evaluate this symptom. Neither subject would consider volunteering for further studies of new hepatitis drugs, but one indicated that it was because he could not take time off from work.

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