Moderate acute toxicity; irritating to eyes and respiratory tract.

The acute toxicity of fluorides is generally moderate. High exposures may cause irritation of the eyes and respiratory tract. Ingestion of fluoride may cause a salty or soapy taste, vomiting, abdominal pain, diarrhea, shortness of breath, difficulty in speaking, thirst, weak pulse, disturbed color vision, muscular weakness, convulsions, loss of consciousness, and death. In humans the approximate lethal dose of NaF by ingestion is 5 g.

Repeated inhalation of fluoride dust may cause excessive calcification of the bone and calcification of ligaments of the ribs, pelvis, and spinal column. Repeated skin contact may cause a rash

Fluorides have not been shown to be carcinogenic or to show reproductive or developmental toxicity in humans.

Fluorides are not combustible.

Contact with strong acids may cause formation of highly toxic and corrosive hydrogen fluoride.

Fluorides should be handled in the laboratory using the "basic prudent practices" described in Chapter 5.C.

In the event of skin contact, immediately wash with soap and water and remove contaminated clothing. In case of eye contact, promptly wash with copious amounts of water for 15 min (lifting upper and lower lids occasionally) and obtain medical attention. If fluorides are ingested, obtain medical attention immediately. If large amounts of fluorides are inhaled, move the person to fresh air and seek medical attention at once.