. "Appendix B: Laboratory Chemical Safety Summaries." Prudent Practices in the Laboratory: Handling and Disposal of Chemicals. Washington, DC: The National Academies Press, 1995.
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Prudent Practices in the Laboratory: Handling and Disposal of Chemicals
Flammability and Explosibility
Methanol is a flammable liquid (NFPA rating = 3) that burns with an invisible flame in daylight; its vapor can travel a considerable distance to an ignition source and "flash back." Methanol-water mixtures will burn unless very dilute. Carbon dioxide or dry chemical extinguishers should be used for methanol fires.
Reactivity and Incompatibility
Methanol can react violently with strong oxidizing agents such as chromium trioxide, with strong mineral acids such as perchloric, sulfuric, and nitric acids, and with highly reactive metals such as potassium. Sodium and magnesium metal react vigorously with methanol.
Storage and Handling
Methanol should be handled in the laboratory using the "basic prudent practices" described in Chapter 5.C, supplemented by the additional precautions for dealing with extremely flammable substances (Chapter 5.F). In particular, methanol should be used only in areas free of ignition sources, and quantities greater than 1 liter should be stored in tightly sealed metal containers in areas separate from oxidizers.
Accidents
In the event of skin contact, immediately wash with soap and water and remove contaminated clothing. In case of eye contact, promptly wash with copious amounts of water for 15 min (lifting upper and lower lids occasionally) and obtain medical attention. If methanol is ingested, obtain medical attention immediately. If large amounts of this compound are inhaled, move the person to fresh air and seek medical attention at once.
In the event of a spill, remove all ignition sources, soak up the methanol with a spill pillow or absorbent material, place in an appropriate container, and dispose of properly. Respiratory protection may be necessary in the event of a large spill or release in a confined area.
Disposal
Excess methanol and waste material containing this substance should be placed in an appropriate container, clearly labeled, and handled according to your institution's waste disposal guidelines. For more information on disposal procedures, see Chapter 7 of this volume.
