highly unstable and explosive. Ozone combines with many aromatic compounds and ethers to form shock-sensitive and explosive products.

Storage and Handling

Because of its high degree of acute toxicity, ozone should be handled in the laboratory using the ''basic prudent practices" described in Chapter 5.C, supplemented by the additional precautions for work with compounds of high toxicity (Chapter 5.D) and high reactivity (Chapter 5.G). In particular, work with ozone should be conducted in a fume hood to prevent exposure by inhalation. Ozone is usually produced in the laboratory with a ozone generator, and care should be taken to ensure adequate ventilation in the area where the ozone generation equipment is located. Because of the possibility of the generation of explosive ozonides, ozonolysis reactions should always be conducted in a fume hood behind a safety shield.


An ozone leak can be easily detected by its characteristic pungent odor. If a large amount of ozone is inhaled, move the person to fresh air and seek medical attention at once. In the event of eye contact, promptly wash eyes with copious amounts of water for 15 min (lifting upper and lower lids occasionally) and obtain medical attention.

Respiratory protection may be necessary in the event of an accidental release of ozone.


Ozone is usually produced on demand from a laboratory ozone generator, and a procedure for the treatment of excess ozone should be included in the experimental plan. Small to moderate amounts of excess ozone can be vented to the fume hood or other exhaust system. When large amounts of excess ozone are anticipated, the excess gas should be passed through a series of traps containing a 1 to 2% solution of potassium iodide or other reducing agent before venting to the fume hood.

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