fumes of trifluoroacetic acid can destroy labels on other bottles if the container is not tightly sealed.


In the event of skin contact, the affected area should be flushed immediately with copious amounts of water. In case of eye contact, promptly wash with copious amounts of water for 15 min (lifting upper and lower lids occasionally). Medical attention should be obtained immediately in the event of contact with a large area of the skin or eye contact. If trifluoroacetic acid is ingested, obtain medical attention immediately. If large amounts of this compound are inhaled, move the person to fresh air and seek medical attention at once.

Carefully neutralize small spills of TFA with a suitable agent such as sodium carbonate, dilute with absorbent material, place in an appropriate container, and dispose of properly. Respiratory protection may be necessary in the event of a large spill or release in a confined area.


Trifluoroacetic acid and waste material containing this substance should be placed in an appropriate container, clearly labeled, and handled according to your institution's waste disposal guidelines. For more information on disposal procedures, see Chapter 7 of this volume.

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